INT163980

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 18
Disease Relevance 4.47
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdc) lyase activity (Hdc) cellular amino acid metabolic process (Hdc)
Anatomy Link Frequency
neurons 6
macrophages 2
TMN 2
brain 1
Hdc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 148 98.72 Very High Very High Very High
Morphine 8 98.56 Very High Very High Very High
Action potential 78 97.60 Very High Very High Very High
adenocard 18 95.48 Very High Very High Very High
cerebral cortex 22 92.44 High High
Dopamine 9 86.80 High High
narcan 1 75.44 Quite High
withdrawal 2 73.68 Quite High
Pain 13 72.92 Quite High
Neurotransmitter 48 71.28 Quite High
Disease Link Frequency Relevance Heat
Suicidal Behaviour 21 99.52 Very High Very High Very High
Crystal Associated Disease 186 99.16 Very High Very High Very High
INFLAMMATION 160 98.72 Very High Very High Very High
Targeted Disruption 42 98.68 Very High Very High Very High
Sprains And Strains 20 97.64 Very High Very High Very High
Obesity 24 94.68 High High
Synovitis 3 87.60 High High
Infection 54 83.08 Quite High
Malaria 16 82.32 Quite High
Appetite Loss 14 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conditioned place preference (CPP) was present in both wild-type (WT) and HDC-KO mice treated with 5 or 10 mg/kg morphine.
Gene_expression (present) of HDC associated with morphine
1) Confidence 0.65 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 19879332 Disease Relevance 0.17 Pain Relevance 0.81
It is striking to observe that, except for naive mice where the amounts of brain t-MeHA were well correlated with levels of HDC gene expression, in infected mice this correlation was poor in both mouse strains.
Gene_expression (expression) of HDC in brain associated with sprains and strains
2) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696087 Disease Relevance 0.63 Pain Relevance 0
Potential roles of PUMA-g, TREM-1, Irg1, PROK-2 and Hdc in the pathogenesis of crystal inflammation
Gene_expression (roles) of Hdc associated with inflammation
3) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.66 Pain Relevance 0.13
To test whether macrophages were also potential sources of Irg1, PROK-2, Hdc and PUMA-g, kinetics of these mRNAs were determined during 18 hours after the addition of MSU crystals to cultured mouse peritoneal macrophages (Figure 5).
Gene_expression (sources) of Hdc in macrophages associated with crystal associated disease
4) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.71 Pain Relevance 0
Consistent with our observation that MSU crystals induced Hdc mRNA synthesis in macrophage culture, with reports of Hdc mRNA expression in neutrophils [39], and with the well documented presence of mast cells in the air pouch membrane [12], all of these three cell types are probably highly inducible sources of Hdc in the pouch membrane.
Spec (probably) Gene_expression (sources) of Hdc in macrophage associated with crystal associated disease
5) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 1.17 Pain Relevance 0.42
The VTM neurons of HDC-KO mice showed no histamine immunoreactivity, but were immunoreactive for the histaminergic (HA) neuron markers adenosine deaminase and glutamic acid decarboxylase 67.
Gene_expression (neurons) of HDC in neurons associated with adenocard
6) Confidence 0.45 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Abstract Doc Link PMC2972729 Disease Relevance 0.17 Pain Relevance 0.08
The mean (±SEM) spontaneous discharge rates of W-specific neurons in HDC-KO mice during AW (4.04 ±?
Gene_expression (neurons) of HDC in neurons
7) Confidence 0.45 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0 Pain Relevance 0.04
W-specific neurons in HDC-KO mice
Gene_expression (neurons) of HDC in neurons
8) Confidence 0.45 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0 Pain Relevance 0.07
The W-specific neurons in HDC-KO mice were located in the VTM region, where W-specific HA neurons were found in WT mice (Figure 1, see also Takahashi et al., 2006).
Gene_expression (neurons) of HDC in neurons
9) Confidence 0.45 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0 Pain Relevance 0.03
The W-specific neurons in HDC-KO mice were all characterized by having a broad triphasic action potential (Figure 3B), with mean durations (D1–D4) not significantly different from those in W-specific neurons in WT mice (P >?
Gene_expression (neurons) of HDC in neurons associated with action potential
10) Confidence 0.45 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0 Pain Relevance 0.07
The VTM W-specific neurons in HDC-KO mice thus displayed exactly the same characteristics as those in WT mice.
Gene_expression (neurons) of HDC in neurons
11) Confidence 0.45 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0 Pain Relevance 0.12
-fluoromethylhistidine (FMH), a suicide inhibitor of histamine synthesizing histidine decarboxylase (HDC) enzyme as well as in mice with targeted disruption of histamine H1 receptors (H1KO mice) (Yoshimatsu et al. 1998; Masaki et al. 2001).
Gene_expression (synthesizing) of HDC associated with targeted disruption and suicidal behaviour
12) Confidence 0.40 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.20 Pain Relevance 0.04
Microinfusion of TRH into the TMN increased t-MH content, histidine decarboxylase (HDC) activity and expression of HDC mRNA in the TMN.
Gene_expression (expression) of HDC in TMN
13) Confidence 0.35 Published 2007 Journal Journal of Neurochemistry Section Abstract Doc Link PMC2156111 Disease Relevance 0.15 Pain Relevance 0
Microinfusion of TRH into the TMN increased t-MH content, histidine decarboxylase (HDC) activity and expression of HDC mRNA in the TMN.
Gene_expression (expression) of HDC in TMN
14) Confidence 0.35 Published 2007 Journal Journal of Neurochemistry Section Abstract Doc Link PMC2156111 Disease Relevance 0.15 Pain Relevance 0
Moreover, TRH at the dose of 1–50 nmol increased HDC expression in a dose-dependent manner (Fig. 6c).


Gene_expression (expression) of HDC
15) Confidence 0.31 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0 Pain Relevance 0.04
Moreover, HDC expression was increased by microinfusion of TRH at 10 and 50 nmol into the TMN but not at 1 nmol dose of TRH.
Gene_expression (expression) of HDC
16) Confidence 0.31 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0 Pain Relevance 0.05
Leptin-induced suppression of feeding was reported to be attenuated both in rats whose histamine was depleted by FMH, a suicide inhibitor of histamine synthesizing HDC enzyme, and in H1KO mice (Yoshimatsu et al. 1998; Masaki et al. 2001).
Gene_expression (synthesizing) of HDC enzyme associated with suicidal behaviour
17) Confidence 0.31 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.26 Pain Relevance 0.03
-fluoromethylhistidine (FMH), a suicide inhibitor of histamine synthesizing histidine decarboxylase (HDC) enzyme as well as in mice with targeted disruption of histamine H1 receptors (H1KO mice) (Yoshimatsu et al. 1998; Masaki et al. 2001).
Gene_expression (synthesizing) of histidine decarboxylase associated with targeted disruption and suicidal behaviour
18) Confidence 0.30 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.20 Pain Relevance 0.04

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