INT163987

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.43
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (FMO3) endoplasmic reticulum (FMO3)
FMO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 30 98.98 Very High Very High Very High
alcohol 21 91.44 High High
palliative 1 64.00 Quite High
Angina 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 141 93.96 High High
Stress 9 74.84 Quite High
Sweat Gland Disease 3 66.36 Quite High
Cardiovascular Disease 90 63.84 Quite High
Inborn Error Of Metabolism 3 60.48 Quite High
Diabetes Mellitus 9 58.84 Quite High
Renal Disease 3 48.20 Quite Low
Stroke 3 47.08 Quite Low
Myocardial Infarction 15 46.76 Quite Low
Inborn Genetic Diseases 3 28.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Females with moderate to severe TMAuria note exacerbations perimenstrually and it is proposed that decreases in FMO3 enzymatic activity resulting from polymorphisms could also be influenced by hormonal events[31].
Negative_regulation (decreases) of FMO3
1) Confidence 0.59 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1316875 Disease Relevance 0.56 Pain Relevance 0.20
Functional analyses of recombinant FMO3 proteins suggested that these FMO3 gene mutations were one of the causal factors for decreased FMO3 function resulting in trimethylaminuria.
Negative_regulation (decreased) of FMO3
2) Confidence 0.43 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881207 Disease Relevance 0 Pain Relevance 0.06
We and others have noted that the E308G polymorphism shows a substantial decrease in FMO3 activity in the presence of the E158K polymorphism causing mild TMAuria[22,29].
Negative_regulation (decrease) of FMO3
3) Confidence 0.43 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1316875 Disease Relevance 0.42 Pain Relevance 0.18
We have identified increased excretion of catecholamines in a proband with TMAuria who is homozygous for a deletion of the FMO3 gene [20]suggesting a possible association between abnormal catecholamine metabolism and variants of the FMO3 gene.
Negative_regulation (deletion) of FMO3 associated with catecholamine
4) Confidence 0.43 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1316875 Disease Relevance 0.45 Pain Relevance 0.21

General Comments

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