INT163990

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.03
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (FMO3) endoplasmic reticulum (FMO3)
Anatomy Link Frequency
liver 2
FMO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 5 98.72 Very High Very High Very High
Catecholamine 20 78.08 Quite High
alcohol 14 50.24 Quite High
Angina 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 94 99.32 Very High Very High Very High
Cardiovascular Disease 60 88.20 High High
Stress 6 33.64 Quite Low
Sweat Gland Disease 2 27.76 Quite Low
Inborn Error Of Metabolism 2 21.88 Low Low
Diabetes Mellitus 6 17.64 Low Low
Renal Disease 2 9.60 Low Low
Stroke 2 8.48 Low Low
Myocardial Infarction 10 8.16 Low Low
Cv General 3 Under Development 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both genetic polymorphisms in the 5'-upstream of the FMO3 gene and some hormonal changes related to menstruation may be causal factors for inter- and/or intra- individual expression levels of FMO3.
Gene_expression (expression) of FMO3
1) Confidence 0.78 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881207 Disease Relevance 0 Pain Relevance 0.10
Both genetic polymorphisms in the 5'-upstream of the FMO3 gene and some hormonal changes related to menstruation may be causal factors for inter- and/or intra- individual expression levels of FMO3.
Gene_expression (expression) of FMO3 gene
2) Confidence 0.78 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881207 Disease Relevance 0 Pain Relevance 0.10
Inter-individual variations of FMO3-mediated microsomal oxygenation activities, levels of FMO3 protein and FMO3 mRNA, and its modification in liver microsomes from Japanese samples were observed.
Gene_expression (levels) of FMO3 in liver
3) Confidence 0.68 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881207 Disease Relevance 0 Pain Relevance 0.07
Inter-individual variations of FMO3-mediated microsomal oxygenation activities, levels of FMO3 protein and FMO3 mRNA, and its modification in liver microsomes from Japanese samples were observed.
Gene_expression (levels) of FMO3 in liver
4) Confidence 0.68 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881207 Disease Relevance 0 Pain Relevance 0.08
Both genetic polymorphisms in the 5'-upstream of the FMO3 gene and some hormonal changes related to menstruation may be causal factors for inter- and/or intra- individual expression levels of FMO3.
Gene_expression (levels) of FMO3
5) Confidence 0.60 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881207 Disease Relevance 0 Pain Relevance 0.10
While these common polymorphisms exhibit some difference in expression of the functional FMO3 enzyme, this effect is minimal in comparison to that of the null mutations.
Gene_expression (expression) of FMO3
6) Confidence 0.60 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1316875 Disease Relevance 0.43 Pain Relevance 0.17
Why are FMO3 variants maintained in population, and in particular the E158K variant?
Gene_expression (variants) of FMO3
7) Confidence 0.59 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1316875 Disease Relevance 0.60 Pain Relevance 0.03

General Comments

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