INT163994

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.45
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 6 85.56 High High
Analgesic 3 62.12 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
fibrosis 11 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fatty Liver 63 91.28 High High
Hepatotoxicity 3 84.92 Quite High
Targeted Disruption 7 76.60 Quite High
Overdose 1 72.92 Quite High
Toxicity 6 53.36 Quite High
Dyslipidemia /

Combined Dyslipidemia

6 39.28 Quite Low
Hypolipidemia 1 13.36 Low Low
Injury 8 11.68 Low Low
Nash(non-alcoholic Steatohepatitis) 27 5.00 Very Low Very Low Very Low
Insulin Resistance 25 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant 24-h rhythmicity was demonstrated for CYP2E1 activity, protein levels and mRNA levels.
Positive_regulation (demonstrated) of CYP2E1 Binding (activity) of
1) Confidence 0.50 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881208 Disease Relevance 0.28 Pain Relevance 0.50
Microsomal oxidation of fatty acids, catalyzed by cytochrome CYP2E1, CYP4A10, CYP4A12, and CYP4A14, which are induced in mouse models of steatosis and steatohepatitis, is a potent source of ROS through uncoupling of their catalytic cycles.
Positive_regulation (induced) of CYP2E1 Binding (cytochrome) of
2) Confidence 0.42 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.17 Pain Relevance 0

General Comments

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