INT163995

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.07
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppig) protein folding (Ppig) nucleus (Ppig)
cytoplasm (Ppig)
Anatomy Link Frequency
liver 2
Ppig (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 39 99.44 Very High Very High Very High
Inflammatory stimuli 4 98.92 Very High Very High Very High
Paracetamol 8 97.84 Very High Very High Very High
cytokine 2 91.96 High High
anticonvulsant 2 82.48 Quite High
Analgesic 5 55.80 Quite High
agonist 18 50.44 Quite High
Bile 79 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 66 99.98 Very High Very High Very High
INFLAMMATION 32 99.44 Very High Very High Very High
Malaria 45 92.64 High High
Inflammatory Bowel Disease 64 91.00 High High
Stress 31 85.56 High High
Rickets 16 84.68 Quite High
Hepatotoxicity 6 80.24 Quite High
Necrosis 2 74.44 Quite High
Cancer 36 74.08 Quite High
Overdose 1 66.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Metabolism by CYP and GSH conjugation are common metabolic pathways for many drugs such as APAP.
Negative_regulation (Metabolism) of Gene_expression (conjugation) of CYP associated with paracetamol
1) Confidence 0.24 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881208 Disease Relevance 0.23 Pain Relevance 0.48
Along this line, it was reported that Plasmodium berghei infection depressed the total content of cytochrome P450s (CYPs) and the expression and activity of several CYP isoforms in the rodent liver [3-6].
Negative_regulation (depressed) of Gene_expression (expression) of CYP in liver associated with infection
2) Confidence 0.05 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.81 Pain Relevance 0.12
For example, expression of hepatic CYP genes can be profoundly decreased by various infectious and inflammatory stimuli, with concomitant clinical and toxicological consequences [Morgan, 1997].
Negative_regulation (decreased) of Gene_expression (expression) of CYP associated with inflammatory stimuli
3) Confidence 0.03 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.63 Pain Relevance 0.18
B not only reveals the possible mechanism underlying the immunosuppressive effects of RIF, but also explains the well recognized decreased expression of hepatic CYP genes during inflammation or infection.
Negative_regulation (decreased) of Gene_expression (expression) of CYP associated with inflammation and infection
4) Confidence 0.03 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.41 Pain Relevance 0.11

General Comments

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