INT163998

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 11.24
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSC) aging (CTSC) Golgi apparatus (CTSC)
endoplasmic reticulum (CTSC) lysosome (CTSC)
Anatomy Link Frequency
groove 1
arm 1
leg 1
CTSC (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 99.74 Very High Very High Very High
Neurotransmitter 2 98.56 Very High Very High Very High
Raphe 2 96.76 Very High Very High Very High
Morphine 2 95.08 Very High Very High Very High
Pain 5 94.52 High High
cva 2 93.92 High High
Migraine 2 93.80 High High
Gabapentin 1 93.76 High High
reflex sympathetic dystrophy 1 91.12 High High
local anesthetic 1 83.64 Quite High
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 570 100.00 Very High Very High Very High
Syndrome 94 100.00 Very High Very High Very High
Amputation 2 99.96 Very High Very High Very High
Spinal Muscular Atrophy 30 99.40 Very High Very High Very High
Progressive Bulbar Palsy 15 98.68 Very High Very High Very High
Infection 12 97.12 Very High Very High Very High
Dementia 36 96.96 Very High Very High Very High
Confusion 3 96.96 Very High Very High Very High
Anxiety Disorder 5 95.24 Very High Very High Very High
Pain 4 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Predictive comparative QSAR modelling of (phenylpiperazinyl-alkyl) oxindoles as selective 5-HT1A antagonists by stepwise regression, PCRA, FA-MLR and PLS techniques.
Gene_expression (regression) of PLS associated with antagonist
1) Confidence 0.65 Published 2010 Journal Eur J Med Chem Section Title Doc Link 20053486 Disease Relevance 0.37 Pain Relevance 0.38
Comparative QSAR study was done on thirtytwo (phenylpiperazinyl-alkyl) oxindoles using stepwise regression, PCRA, FA-MLR and PLS techniques to find structurally significant models.
Gene_expression (regression) of PLS
2) Confidence 0.65 Published 2010 Journal Eur J Med Chem Section Abstract Doc Link 20053486 Disease Relevance 0.37 Pain Relevance 0.36
We note, however, that many of the residues that form the traversing groove are homologous with residues of human cathepsin C, and so relevant cruzain inhibitors are likely to inhibit cathepsin C as well.
Gene_expression (residues) of cathepsin C in groove
3) Confidence 0.65 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0.20 Pain Relevance 0
V16 is analogous to the cathepsin C residue V249.
Gene_expression (residue) of cathepsin C
4) Confidence 0.65 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0.16 Pain Relevance 0
Saxagliptin is a potent, reversible, competitive DPP-4 inhibitor that selectively inhibits DPP-4.16 This is in contrast to its effects on other DPP enzymes, including DPP-8 and DPP-9.16 Based on calculated binding affinities to DPP-4, saxagliptin is 10-fold more potent than either sitagliptin or vildagliptin, although this does not translate clinically.16,21,26 Saxagliptin exhibits prolonged binding to the DPP-4 active site, which results in an extended inhibition of this enzyme.16,26
Gene_expression (enzymes) of DPP
5) Confidence 0.65 Published 2010 Journal Core Evidence Section Body Doc Link PMC2963920 Disease Relevance 0.22 Pain Relevance 0.07
After amputation, PLS appeared immediately and was not responsive to pharmacological treatment.
Gene_expression (appeared) of PLS associated with syndrome and amputation
6) Confidence 0.59 Published 2009 Journal Minerva Anestesiol Section Abstract Doc Link 19881462 Disease Relevance 1.21 Pain Relevance 0.88
Other syndromes related to this spectrum of disorders include, Progressive bulbar palsy (PBP), Progressive muscular atrophy (PMA), Primary lateral sclerosis (PLS), Flail arm syndrome (Vulpian-Bernhardt syndrome), Flail leg syndrome (Pseudopolyneuritic form) and ALS with multi-system involvement (e.g., ALS-Dementia).
Gene_expression (syndrome) of PLS in leg associated with dementia, syndrome, progressive bulbar palsy, motor neuron diseases and spinal muscular atrophy
7) Confidence 0.04 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 3.25 Pain Relevance 0
Prognosis for PLS is considerably better than for typical ALS [72].
Gene_expression (Prognosis) of PLS associated with motor neuron diseases
8) Confidence 0.04 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 2.26 Pain Relevance 0
Other syndromes related to this spectrum of disorders include, Progressive bulbar palsy (PBP), Progressive muscular atrophy (PMA), Primary lateral sclerosis (PLS), Flail arm syndrome (Vulpian-Bernhardt syndrome), Flail leg syndrome (Pseudopolyneuritic form) and ALS with multi-system involvement (e.g., ALS-Dementia).
Gene_expression (syndrome) of PLS in arm associated with dementia, syndrome, progressive bulbar palsy, motor neuron diseases and spinal muscular atrophy
9) Confidence 0.04 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 3.21 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox