INT164017

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.12
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
Anatomy Link Frequency
fat 4
hypothalamus 2
Ghrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 95 99.98 Very High Very High Very High
Somatostatin 35 95.28 Very High Very High Very High
Pain 14 92.72 High High
Cholecystokinin 5 90.92 High High
Pain threshold 10 89.64 High High
Dopamine 10 88.56 High High
medulla 20 87.44 High High
Cannabinoid 10 86.28 High High
agonist 85 77.84 Quite High
vagus nerve 15 74.48 Quite High
Disease Link Frequency Relevance Heat
Eating Disorder 1 99.90 Very High Very High Very High
Obesity 87 99.84 Very High Very High Very High
Appetite Loss 67 99.40 Very High Very High Very High
Pain 22 92.72 High High
Hyperinsulinism 20 85.84 High High
Targeted Disruption 85 82.28 Quite High
Insulin Resistance 25 81.04 Quite High
Aging 15 73.36 Quite High
Nociception 8 71.00 Quite High
Syndrome 15 69.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circulating ghrelin levels negatively correlate with BMI, meaning increased ghrelin secretion during fasting, malnutrition, cachexia, and in anorexia nervosa and reduced ghrelin secretion in obesity.
Negative_regulation (reduced) of Localization (secretion) of ghrelin associated with appetite loss, obesity and eating disorder
1) Confidence 0.53 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19883981 Disease Relevance 2.09 Pain Relevance 0.94
For example, intestinal mucosal L-cell-derived oxyntomodulin, a satiety signal, acts via the hypothalamus to inhibit vagally driven gastric secretion of acylghrelin, thus quelling hunger [363].
Negative_regulation (inhibit) of Localization (secretion) of ghrelin in hypothalamus
2) Confidence 0.42 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.30 Pain Relevance 0.08
The cephalic (meal-visualization) phase of digestion in humans clearly depends on vagal efferents, which transduce prandial inhibition of ghrelin secretion [500].
Negative_regulation (inhibition) of Localization (secretion) of ghrelin
3) Confidence 0.31 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.05 Pain Relevance 0.04
In addition, a CCK antagonist abolishes the capability of intraduodenal fat to suppress gastric ghrelin secretion [339], consistent with gastroduodenal feedback [340].
Negative_regulation (abolishes) of Localization (secretion) of ghrelin in fat associated with antagonist
4) Confidence 0.27 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.07 Pain Relevance 0.38
In humans, glucagon injection inhibits ghrelin secretion [121], but via uncertain pathways.
Negative_regulation (inhibits) of Localization (secretion) of ghrelin
5) Confidence 0.20 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.54 Pain Relevance 0.07
In addition, a CCK antagonist abolishes the capability of intraduodenal fat to suppress gastric ghrelin secretion [339], consistent with gastroduodenal feedback [340].
Negative_regulation (suppress) of Localization (secretion) of ghrelin in fat associated with antagonist
6) Confidence 0.20 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.07 Pain Relevance 0.37

General Comments

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