INT16404

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Context Info
Confidence 0.61
First Reported 1991
Last Reported 2011
Negated 10
Speculated 3
Reported most in Body
Documents 54
Total Number 57
Disease Relevance 33.05
Pain Relevance 10.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cell 14
regulatory T cells 9
lymphocyte 4
plasma 2
blood 2
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 29 100.00 Very High Very High Very High
addiction 103 99.96 Very High Very High Very High
Inflammation 485 99.88 Very High Very High Very High
cINOD 13 99.70 Very High Very High Very High
cytokine 382 99.56 Very High Very High Very High
Arthritis 253 99.44 Very High Very High Very High
rheumatoid arthritis 292 99.38 Very High Very High Very High
Acupuncture 56 99.08 Very High Very High Very High
chemokine 87 98.40 Very High Very High Very High
Pain 49 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 396 100.00 Very High Very High Very High
INFLAMMATION 485 99.88 Very High Very High Very High
Juvenile Chronic Polyarthritis 176 99.84 Very High Very High Very High
Systemic Lupus Erythematosus 147 99.84 Very High Very High Very High
Cryptococcal Meningitis 27 99.84 Very High Very High Very High
Influenza Virus Infection 94 99.80 Very High Very High Very High
Papillomavirus Infection 27 99.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1502 99.68 Very High Very High Very High
Rheumatoid Arthritis 295 99.46 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 65 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ten asymptomatic HIV-seropositive men participated in a randomized, placebo-controlled, cross-over pilot study to determine effects of indomethacin on their CD4 ('helper') and CD8 ('suppressor') cell counts.
Regulation (effects) of CD4 associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.61 Published 1991 Journal Clin Invest Med Section Abstract Doc Link 1829401 Disease Relevance 0.70 Pain Relevance 0.32
The beneficial effect of these new treatments on viral load and CD4 levels has made a considerable contribution to improving patientsÂ’ state of health and reducing morbidity, mortality and hospitalization [4].
Regulation (effect) of CD4
2) Confidence 0.60 Published 2009 Journal The Open Nursing Journal Section Body Doc Link PMC2698420 Disease Relevance 0.72 Pain Relevance 0
Each treatment was well-tolerated in terms of side effects, and there was essentially no effect of any treatment on CD4 cell count.
Neg (no) Regulation (effect) of CD4
3) Confidence 0.45 Published 1996 Journal Compr Psychiatry Section Abstract Doc Link 8932964 Disease Relevance 0.45 Pain Relevance 0.29
For program enrollees in 1988-1989, the HR was 1.0 [95% confidence interval (CI) = 0.6-1.6]; for enrollees in 1990-1991, the HR was 0.3 (95% CI = 0.1-0.9); for enrollees in 1992-1993, the HR was 0.5 (95% CI = 0.3-0.9); and for enrollees in 1994-1995, the HR was 0.2 (95% CI = 0.1-0.7), after controlling on initial CD4+ cell counts and age.
Regulation (controlling) of CD4
4) Confidence 0.45 Published 1998 Journal Epidemiology Section Abstract Doc Link 9799169 Disease Relevance 0.84 Pain Relevance 0.08
The objective was to examine the effect of methadone on CD4+ lymphocyte counts and viral load and to expect to document the safety of methadone maintenance in patients with human immune deficiency syndrome.
Spec (examine) Regulation (effect) of CD4 in lymphocyte associated with syndrome and methadone
5) Confidence 0.45 Published 2001 Journal Eur J Pain Section Abstract Doc Link 11743707 Disease Relevance 0.48 Pain Relevance 0.55
Long-term methadone treatment: effect on CD4+ lymphocyte counts and HIV-1 plasma RNA level in patients with HIV infection.
Regulation (effect) of CD4 in plasma associated with acquired immune deficiency syndrome or hiv infection, methadone and infection
6) Confidence 0.45 Published 2001 Journal Eur J Pain Section Title Doc Link 11743707 Disease Relevance 0.60 Pain Relevance 0.78
This means that a restrictive CD4 threshold for treatment initiation will also be counterproductive in attempting to allocate resources fairly; "doing less with more" in this area also implies depriving others of needed interventions towards which these resources could otherwise have been channelled.
Regulation (counterproductive) of CD4
7) Confidence 0.45 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.18 Pain Relevance 0
After controlling for CD4+ cell count, adult on HAART had a significantly lower risk of oral Kaposi's sarcoma compared with those not on HAART (adjusted OR = 0.29; 95% CI = 0.10–0.89; p < 0.03).
Regulation (controlling) of CD4 associated with sarcoma
8) Confidence 0.45 Published 2006 Journal BMC Oral Health Section Body Doc Link PMC1559688 Disease Relevance 1.38 Pain Relevance 0.07
The viral load, which is used to predict changes in CD4+ T cell count in the near future, is associated with the prognosis.
Regulation (changes) of CD4 in T cell
9) Confidence 0.45 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2824091 Disease Relevance 1.00 Pain Relevance 0
As in blood, the entire CD4+ T cell population in the lymph nodes bound the DARPins.
Regulation (population) of CD4 in T cell
10) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0 Pain Relevance 0
In the control study, there were no changes in the CD4/CD8 ratio.
Neg (no) Regulation (changes) of CD4
11) Confidence 0.44 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 16437735 Disease Relevance 0.48 Pain Relevance 0.12
Besides these established therapies, recent research has focused on cytokine related therapies to modulate CD4+CD25high regulatory T cell function.
Regulation (modulate) of CD4 in regulatory T cell associated with cytokine
12) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.25 Pain Relevance 0.21
The occasionally reported reduction in numbers of CD4+CD25high regulatory T cells in the circulation may result from their recruitment to sites of inflammation.
Regulation (regulatory T cells) of CD4 in regulatory T cells associated with inflammation
13) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.89 Pain Relevance 0.29
Yan et al. found no difference in Foxp3 expression in CD4+CD25high regulatory T cells of SLE patients [134].
Regulation (regulatory T cells) of CD4 in regulatory T cells associated with systemic lupus erythematosus
14) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.25 Pain Relevance 0.11
As described above, rapamycin preferentially expands CD4+CD25high regulatory T cells.
Regulation (regulatory T cells) of CD4 in regulatory T cells
15) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.40 Pain Relevance 0.18
Research on CD4+CD25high regulatory T cells in juvenile idiopathic arthritis (JIA) has revealed distinct abnormalities in function and distribution in various disease subtypes.
Regulation (regulatory T cells) of CD4 in juvenile associated with congenital anomalies, disease, juvenile chronic polyarthritis and arthritis
16) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.37 Pain Relevance 0.31
Early attempts to characterize CD4+CD25high regulatory T cells were flawed due to use of high surface expression of CD25 as the single cell marker and the resulting inclusion of variable numbers of activated T effector cells over the course of disease.
Regulation (regulatory T cells) of CD4 in regulatory T cells associated with disease
17) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.96 Pain Relevance 0.04
A trial using third party cord blood CD4+CD25high regulatory T cell in patients with SCT has been recently initiated at the University of Minnesota (Dr.
Regulation (regulatory T cell) of CD4 in blood
18) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.70 Pain Relevance 0.20
CD4+CD25high regulatory T cells as a treatment in autoimmune and rheumatic diseases
Regulation (regulatory T cells) of CD4 in regulatory T cells associated with rheumatic diseases
19) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.92 Pain Relevance 0.38
In contrast, we find reduced levels of circulating CD4+CD25high regulatory T cells in polyarticular JIA (unpublished data).
Regulation (regulatory T cells) of CD4 in regulatory T cells associated with arthritis
20) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.70 Pain Relevance 0.32

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