INT16405

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Context Info
Confidence 0.45
First Reported 1991
Last Reported 2010
Negated 10
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 19.04
Pain Relevance 5.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T cells 13
lymphocyte 4
blood 1
nerves 1
B-cells 1
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 209 100.00 Very High Very High Very High
rheumatoid arthritis 45 100.00 Very High Very High Very High
cINOD 20 99.70 Very High Very High Very High
Acupuncture 56 99.08 Very High Very High Very High
methotrexate 28 98.44 Very High Very High Very High
withdrawal 17 97.60 Very High Very High Very High
Pain 20 97.28 Very High Very High Very High
narcan 2 95.92 Very High Very High Very High
chemokine 14 94.68 High High
Inflammation 145 93.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 160 100.00 Very High Very High Very High
Rheumatoid Arthritis 101 100.00 Very High Very High Very High
Disease 149 99.84 Very High Very High Very High
Multiple Sclerosis 87 99.48 Very High Very High Very High
Autoimmune Disease 61 99.48 Very High Very High Very High
Adverse Drug Reaction 1 99.32 Very High Very High Very High
Systemic Lupus Erythematosus 13 99.28 Very High Very High Very High
Parasitemia 64 98.60 Very High Very High Very High
Adult T-cell Leukemia-lymphoma 11 98.56 Very High Very High Very High
Diffuse Cutaneous Leishmaniasis 222 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ten asymptomatic HIV-seropositive men participated in a randomized, placebo-controlled, cross-over pilot study to determine effects of indomethacin on their CD4 ('helper') and CD8 ('suppressor') cell counts.
Regulation (effects) of CD8 associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.45 Published 1991 Journal Clin Invest Med Section Abstract Doc Link 1829401 Disease Relevance 0.70 Pain Relevance 0.32
As a positive control for CD8+ T cell reactivity, all samples were stimulated with a collection of WNV-specific CD8+ T cell epitopes that was previously found to be frequently recognised in any given patient [10].
Regulation (control) of CD8 in T cell
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0 Pain Relevance 0
The effects of nonsteroidal antiinflammatory drug therapy in early rheumatoid arthritis on serum levels of soluble interleukin 2 receptor, CD4, and CD8.
Regulation (effects) of CD8 associated with inflammation and rheumatoid arthritis
3) Confidence 0.34 Published 1993 Journal J. Rheumatol. Section Title Doc Link 8308770 Disease Relevance 0.48 Pain Relevance 0.27
MDC and PDC percentages did not change after CD8+ cell depletion (data not shown).
Neg (not) Regulation (change) of CD8
4) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 0.42 Pain Relevance 0
We observed a recovery of the CD8 effector functions, including cytotoxicity, IFN?
Regulation (recovery) of CD8
5) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 1.28 Pain Relevance 0
The CD2+, CD4+ and CD8+ levels, which are closely associated with activity of T cells, were statistically unchanged except on day 8 after acupuncture (P < 0.05).
Regulation (unchanged) of CD8 in T cells associated with acupuncture
6) Confidence 0.30 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.27
Furthermore, multiple studies have also demonstrated that in vivo IL-2 administration in humans has minimal effects on CD8+ T cells numbers (37, 38).
Regulation (effects) of CD8 in T cells
7) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
No CD8+ T cell cytokine response was observed (Figure 1B).
Neg (No) Regulation (response) of CD8 in T cell associated with cytokine
8) Confidence 0.27 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.36 Pain Relevance 0.25
In the course of rheumatoid arthritis (RA), the NSAID are unable to modify the ratio CD4/CD8.
Neg (unable) Regulation (modify) of CD8 associated with cinod and rheumatoid arthritis
9) Confidence 0.26 Published 1991 Journal Rev Rhum Mal Osteoartic Section Abstract Doc Link 2057729 Disease Relevance 0.43 Pain Relevance 0.64
While this is in accordance with a study conducted by Lu et al. [40], Hasegawa et al. have shown that only DcR2 expression but no other TRAIL receptor expression was detectable on CD8+ T cells [41].
Regulation (detectable) of CD8 in T cells
10) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 1.08 Pain Relevance 0.15
The immunological study showed low values of CD4 in presence of normal values of CD8 and of a normal natural killer function.
Regulation (values) of CD8
11) Confidence 0.23 Published 2000 Journal Recenti Prog Med Section Abstract Doc Link 10705779 Disease Relevance 1.31 Pain Relevance 0.07
No alterations of CD4+/CD8, CD8+bright/CD57+, CD8+dim/ CD57+/- cells and sCD4 were observed.
Neg (No) Regulation (alterations) of CD8
12) Confidence 0.21 Published 2003 Journal Minerva Med. Section Body Doc Link 12858157 Disease Relevance 0.07 Pain Relevance 0
Knocking out MHC class I expression in the SLE prone mouse suggested an important role for CD8+ T cells in autoimmunity as it failed to develop SLE [62].
Regulation (role) of CD8 in T cells associated with autoimmune disease and systemic lupus erythematosus
13) Confidence 0.20 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.78 Pain Relevance 0.24
In the next stage, we examined the influence of aromatherapy and massage on hematocrit, and lymphocyte, CD8+ and CD16+ cell counts using two-way ANOVA.
Spec (examined) Regulation (influence) of CD8 in lymphocyte
14) Confidence 0.19 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1142199 Disease Relevance 0.25 Pain Relevance 0.03
In the control study, there were no changes in the CD4/CD8 ratio.
Neg (no) Regulation (changes) of CD8
15) Confidence 0.19 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 16437735 Disease Relevance 0.48 Pain Relevance 0.12
The marked response of CD8 towards Leishmania parasites led us to analyze possible functional differences between CD8 from patients with LCL and DCL.
Regulation (response) of CD8 in CD8
16) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2970528 Disease Relevance 0.41 Pain Relevance 0.04
The marked response of CD8 towards Leishmania parasites led us to analyze possible functional differences between these cells from patients with LCL and DCL.
Regulation (response) of CD8 associated with leishmaniasis and diffuse cutaneous leishmaniasis
17) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 1.16 Pain Relevance 0
The changes in the percentages of CD4+ and CD8+ were slight or moderate in nearly all patients and no consistent pattern was evident.
Regulation (changes) of CD8
18) Confidence 0.18 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3004381 Disease Relevance 0.14 Pain Relevance 0
The secondary endpoints were immunological – changes in CD4, CD8, CD25, CD69 and CD71.
Regulation (changes) of CD8
19) Confidence 0.17 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.25 Pain Relevance 0.10
Overall inter-experiments and inter-operators CV were 19 % and 15 % for antigen-specific CD4 and CD8 response, respectively.
Regulation (response) of CD8
20) Confidence 0.16 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.41 Pain Relevance 0.14

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