INT16406

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 1999
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.53
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) intracellular (Ddc) cellular amino acid metabolic process (Ddc)
cytoplasm (Ddc)
Anatomy Link Frequency
medulla 3
pons 1
Ddc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 5 100.00 Very High Very High Very High
Dopamine 16 99.84 Very High Very High Very High
alcohol 8 99.44 Very High Very High Very High
Serotonin 9 99.36 Very High Very High Very High
medulla 8 99.12 Very High Very High Very High
midbrain 2 98.56 Very High Very High Very High
sSRI 2 97.44 Very High Very High Very High
fluoxetine 5 95.84 Very High Very High Very High
antagonist 3 95.36 Very High Very High Very High
Catecholamine 2 92.32 High High
Disease Link Frequency Relevance Heat
Hypotension 5 99.76 Very High Very High Very High
Coronary Artery Disease 2 75.00 Quite High
Hyperphagia 1 60.48 Quite High
Appetite Loss 1 53.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hypothalamic nuclei of the alcohol-preferring AA rats contained slightly more serotonin than those of the alcohol-avoiding ANA rats, but the accumulation of 5-hydroxytryptophan after inhibition of aromatic amino acid decarboxylase was the same in both lines.
Positive_regulation (accumulation) of Negative_regulation (inhibition) of aromatic amino acid decarboxylase associated with serotonin and alcohol
1) Confidence 0.67 Published 1991 Journal Alcohol Section Abstract Doc Link 1829611 Disease Relevance 0.11 Pain Relevance 0.64
Serotonin synthesis, as estimated by the accumulation of 5-hydroxytryptophan 25 min following aromatic-L-amino acid decarboxylase inhibition, was measured in the medulla, pons-midbrain and posterior and anterior hypothalamus of rats subjected to left coronary artery ligation and their sham-operated controls.
Positive_regulation (accumulation) of Negative_regulation (inhibition) of aromatic-L-amino acid decarboxylase in medulla associated with medulla, midbrain and serotonin
2) Confidence 0.50 Published 1981 Journal Neurosci. Lett. Section Abstract Doc Link 7322452 Disease Relevance 0.07 Pain Relevance 0.45
Hippocampal serotonin (5-hydroxytryptamine, 5-HT) synthesis, as determined by the accumulation of 5-hydroxytryptophan (5-HTP) following inhibition of L-aromatic amino acid decarboxylase with NSD 1015, was inhibited by systemic administration of the selective serotonin reuptake inhibitors fluoxetine (10 mg/kg i.p.) and paroxetine (3 mg/kg i.p.).
Spec (determined) Positive_regulation (accumulation) of Negative_regulation (inhibition) of L-aromatic amino acid decarboxylase associated with ssri, serotonin and fluoxetine
3) Confidence 0.50 Published 1999 Journal Synapse Section Abstract Doc Link 10025679 Disease Relevance 0 Pain Relevance 0.40
In rats with partial, unilateral lesions of the dopaminergic nigrostriatal pathway, synthesis of dopamine (DA) per surviving neurone was assessed by measuring the ratio of DOPA accumulated after inhibition of aromatic amino acid decarboxylase to dopamine (DOPA/DA ratio).
Positive_regulation (accumulated) of Negative_regulation (inhibition) of aromatic amino acid decarboxylase associated with dopamine
4) Confidence 0.43 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.47
Inhibition of either peripheral L-aminoacid DOPA decarboxylase or monoamine oxydase enzymes increased this hypotensive effect. 3.
Positive_regulation (increased) of Negative_regulation (Inhibition) of L-aminoacid DOPA decarboxylase associated with hypotension and monoamine
5) Confidence 0.39 Published 1982 Journal Gen. Pharmacol. Section Abstract Doc Link 6983471 Disease Relevance 0.26 Pain Relevance 0.20
Serotonin synthesis, as estimated by the accumulation of 5-hydroxytryptophan 25 min following aromatic-L-amino acid decarboxylase inhibition, was measured in the medulla, pons-midbrain and posterior and anterior hypothalamus of rats subjected to left coronary artery ligation and their sham-operated controls.
Positive_regulation (accumulation) of in pons Negative_regulation (inhibition) of aromatic-L-amino acid decarboxylase in medulla associated with medulla, midbrain and serotonin
6) Confidence 0.17 Published 1981 Journal Neurosci. Lett. Section Abstract Doc Link 7322452 Disease Relevance 0.07 Pain Relevance 0.45

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