INT164079

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 2.00
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CTGF) Golgi apparatus (CTGF) cytosol (CTGF)
extracellular space (CTGF) extracellular region (CTGF) proteinaceous extracellular matrix (CTGF)
Anatomy Link Frequency
fibroblast 4
knees 2
CTGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 18 97.80 Very High Very High Very High
Pain 4 91.04 High High
corticosteroid 1 34.12 Quite Low
cytokine 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 11 99.40 Very High Very High Very High
Osteoarthritis 18 97.80 Very High Very High Very High
Pain 4 91.04 High High
Apoptosis 3 88.48 High High
Neurodegenerative Disease 1 56.08 Quite High
Osteoporosis 5 20.96 Low Low
Injury 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Wound Healing 3 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro.
Regulation (modulates) of Gene_expression (expression) of CTGF in fibroblast associated with osteoarthritis
1) Confidence 0.44 Published 2010 Journal J. Orthop. Res. Section Title Doc Link 19890996 Disease Relevance 0.57 Pain Relevance 0.30
Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro.
Regulation (modulates) of Gene_expression (expression) of connective tissue growth factor in fibroblast associated with osteoarthritis
2) Confidence 0.44 Published 2010 Journal J. Orthop. Res. Section Title Doc Link 19890996 Disease Relevance 0.57 Pain Relevance 0.29
In this study, after human synovial cells were stimulated with HA and Hylan (Synvisc) for 24 h, real-time polymerase chain reaction (real-time PCR) was used to detect the alteration of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) gene expression, which were specific genes related to pathogenesis of OA knees.
Regulation (alteration) of Gene_expression (expression) of connective tissue growth factor in knees associated with osteoarthritis
3) Confidence 0.26 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19890996 Disease Relevance 0.62 Pain Relevance 0.31
Expression of at least two of these genes, CTGF and COL12A1, is controlled by mechanical strain.
Regulation (controlled) of Gene_expression (Expression) of CTGF associated with sprains and strains
4) Confidence 0.23 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2527292 Disease Relevance 0.25 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox