INT16408

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Context Info
Confidence 0.53
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 5.49
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
plasma 3
spinal 1
medulla 1
cerebral cortex 1
Heart 1
Nppb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Buprenorphine 14 100.00 Very High Very High Very High
medulla 4 98.84 Very High Very High Very High
Opioid 2 98.68 Very High Very High Very High
cerebral cortex 4 98.60 Very High Very High Very High
Dopamine 4 98.24 Very High Very High Very High
antagonist 8 97.56 Very High Very High Very High
narcan 4 95.64 Very High Very High Very High
IPN 2 94.60 High High
adenocard 1 92.76 High High
agonist 7 91.44 High High
Disease Link Frequency Relevance Heat
Dyspnea 59 100.00 Very High Very High Very High
Renal Disease 27 100.00 Very High Very High Very High
Acute Decompensated Heart Failure (ADHF) 22 99.12 Very High Very High Very High
Obesity 57 97.72 Very High Very High Very High
Nociception 2 96.56 Very High Very High Very High
Natriuresis 87 96.36 Very High Very High Very High
Inflammatory Pain 2 94.60 High High
Hyperalgesia 2 84.80 Quite High
Heart Rate Under Development 34 82.56 Quite High
INFLAMMATION 2 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These changes were associated with a decrease in plasma ANP, BNP and ET-1 concentrations.
Negative_regulation (decrease) of BNP in plasma
1) Confidence 0.53 Published 2001 Journal Cardiovasc. Res. Section Body Doc Link 11476752 Disease Relevance 0.06 Pain Relevance 0
Previous studies with levosimendan have demonstrated a reduction in plasma BNP concentrations, correlating with improvements in haemodynamic status in ADHF patients.7 Consistent with these findings, BNP levels were lower during levosimendan treatment and the difference between treatments was statistically significant at 48 h in the present study.
Negative_regulation (reduction) of BNP in plasma associated with acute decompensated heart failure (adhf)
2) Confidence 0.46 Published 2010 Journal European Journal of Heart Failure Section Body Doc Link PMC2844760 Disease Relevance 0.31 Pain Relevance 0
This was confirmed by a small study that consecutively measured both NT-proBNP and BNP in subjects undergoing bariatric surgery.
Negative_regulation (measured) of NT-proBNP
3) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.39 Pain Relevance 0
Importantly, while observational analyses regarding the effects of renal disease on natriuretic peptide values are important, the real matter at hand is optimal application of these markers for clinical use, and the available data suggest that when used at optimal cut-points, NT-proBNP is powerfully diagnostic and prognostic in patients with renal disease and dyspnea.4,90 Indeed, when examining the available literature regarding BNP testing in renal disease in comparable populations,100 it is hard to find much of a difference between NT-proBNP and BNP testing in renal disease: both are affected, but both are valuable in these patients.
Negative_regulation (affected) of NT-proBNP associated with natriuresis, renal disease and dyspnea
4) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.94 Pain Relevance 0
This was confirmed by a small study that consecutively measured both NT-proBNP and BNP in subjects undergoing bariatric surgery.
Negative_regulation (measured) of BNP
5) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.40 Pain Relevance 0
In the cerebral cortex and medulla, the direction of the effect on rCMRglc was opposite for BNP (22% decrease at the dose of 200 micrograms/kg) and PTZ (22% increase at the dose of 10 mg/kg).
Negative_regulation (decrease) of BNP in medulla associated with medulla and cerebral cortex
6) Confidence 0.36 Published 1997 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9331984 Disease Relevance 0 Pain Relevance 0.72
Previous studies with levosimendan have demonstrated a reduction in plasma BNP concentrations, correlating with improvements in haemodynamic status in ADHF patients.7 Consistent with these findings, BNP levels were lower during levosimendan treatment and the difference between treatments was statistically significant at 48 h in the present study.
Negative_regulation (lower) of BNP in plasma associated with acute decompensated heart failure (adhf)
7) Confidence 0.34 Published 2010 Journal European Journal of Heart Failure Section Body Doc Link PMC2844760 Disease Relevance 0.40 Pain Relevance 0
It was concluded that components of ANP and BNP suppression of LH secretion may depend upon opioid and dopamine activity.
Negative_regulation (suppression) of BNP associated with dopamine and opioid
8) Confidence 0.34 Published 1991 Journal Endocrinology Section Abstract Doc Link 1830270 Disease Relevance 0.07 Pain Relevance 0.50
The efflux transport of [3H]BNP was inhibited by range from 32 to 64% in the presence of P-gp inhibitors.
Negative_regulation (inhibited) of BNP associated with buprenorphine
9) Confidence 0.31 Published 2007 Journal J Drug Target Section Abstract Doc Link 17365275 Disease Relevance 0 Pain Relevance 0.82
In the case patient, at eleven months of follow-up and cardiac medication, NT-proBNP had decreased to a level within normal limits (110 ng/L).
Negative_regulation (decreased) of NT-proBNP
10) Confidence 0.18 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475607 Disease Relevance 0.11 Pain Relevance 0
A similar prognostic value of NT-proBNP was demonstrated for cardiovascular mortality (HR, 5.98 [1.55 to 23.13] for the fourth versus the first quartile) and for patients with New York Heart Association class I and II (HR, 6.03 [2.07 to 17.52] for the fourth versus the first quartile).
Negative_regulation (value) of NT-proBNP in Heart
11) Confidence 0.15 Published 2005 Journal Circulation Section Body Doc Link 16186420 Disease Relevance 0.07 Pain Relevance 0
In the cerebral cortex and medulla, the direction of the effect on rCMRglc was opposite for BNP (22% decrease at the dose of 200 micrograms/kg) and PTZ (22% increase at the dose of 10 mg/kg).
Negative_regulation (decrease) of BNP in cerebral cortex associated with medulla and cerebral cortex
12) Confidence 0.12 Published 1997 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9331984 Disease Relevance 0 Pain Relevance 0.72
The inhibitory effect of Iso was blocked by propranolol, but not by metoprolol, a beta 1-antagonist.
Negative_regulation (effect) of Iso associated with antagonist
13) Confidence 0.08 Published 1995 Journal Endocrinology Section Abstract Doc Link 7789340 Disease Relevance 0.15 Pain Relevance 0.27
Specifically, spinal administration of a MIF inhibitor (ISO-1) prevented and reversed flinching responses in rats.
Negative_regulation (inhibitor) of ISO-1 in spinal
14) Confidence 0.05 Published 2010 Journal Pain Section Abstract Doc Link 20005040 Disease Relevance 0.59 Pain Relevance 0.59
These "new" coxibs are the final step in the theory of COX-2 selectivity and they will probably be helpful to better define the limitations of the therapeutic concept based on a selective inhibition of this iso-enzyme.
Negative_regulation (inhibition) of iso-enzyme
15) Confidence 0.00 Published 2004 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 15366670 Disease Relevance 0 Pain Relevance 0.11

General Comments

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