INT1641

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Context Info
Confidence 0.41
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.70
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
plasma 2
follicle 2
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 15 99.32 Very High Very High Very High
Clonidine 6 98.52 Very High Very High Very High
opiate 1 98.36 Very High Very High Very High
Endogenous opioid 2 88.16 High High
vaginimus 14 83.32 Quite High
withdrawal 1 82.48 Quite High
Opioid 1 75.00 Quite High
antagonist 45 30.52 Quite Low
agonist 35 5.00 Very Low Very Low Very Low
antidepressant 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 55 95.68 Very High Very High Very High
Endometriosis (extended) 37 91.96 High High
Polycystic Ovary Syndrome 12 91.80 High High
Reprotox - General 1 98 83.32 Quite High
Obesity 11 80.08 Quite High
Urinary Tract Infection 1 73.72 Quite High
Frailty 7 62.64 Quite High
Stress Incontinence 1 60.88 Quite High
Body Weight 2 56.40 Quite High
Reprotox - General 3 48 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results obtained point also to a possible different pattern of LH and FSH secretion after naloxone, that is after opiate receptor blockade.
Spec (possible) Positive_regulation (point) of Spec (possible) Negative_regulation (pattern) of FSH associated with narcan and opiate
1) Confidence 0.41 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 223091 Disease Relevance 0 Pain Relevance 0.94
CRH infusion induced a significant decrease in plasma LH and FSH levels in all women.
Positive_regulation (induced) of Negative_regulation (decrease) of FSH in plasma
2) Confidence 0.28 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2493035 Disease Relevance 0 Pain Relevance 0.30
These changes are not likely to be a direct action of FSH because FSH decreases as E2 and leptin rise during natural cycles, and high FSH levels experienced during ovarian stimulation simulate endogenous levels in postmenopausal women, who have lower serum leptin concentrations than premenopausal women [205].
Positive_regulation (rise) of Negative_regulation (decreases) of FSH
3) Confidence 0.20 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.48 Pain Relevance 0
At weeks 2, 12, and 24, increases in serum estradiol concentrations and suppression of follicle-stimulating hormone (FSH) were observed in significantly more patients who were using the vaginal cream than in those who were using the vaginal tablets (p?
Positive_regulation (increases) of Negative_regulation (suppression) of follicle-stimulating hormone in follicle
4) Confidence 0.17 Published 2010 Journal J Cancer Surviv Section Body Doc Link PMC2921487 Disease Relevance 1.23 Pain Relevance 0.19

General Comments

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