INT164116

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Context Info
Confidence 0.51
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 18.73
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (1190002H23Rik) nucleus (1190002H23Rik) cell cycle (1190002H23Rik)
cytoplasm (1190002H23Rik)
Anatomy Link Frequency
optic nerve 6
retina 4
eyes 3
RGC 3
oligodendrocyte 3
1190002H23Rik (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 69 99.82 Very High Very High Very High
Neuritis 21 99.44 Very High Very High Very High
nMDA receptor 4 99.16 Very High Very High Very High
tetrodotoxin 18 99.08 Very High Very High Very High
corticosteroid 21 98.74 Very High Very High Very High
withdrawal 19 98.72 Very High Very High Very High
Glutamate 48 98.10 Very High Very High Very High
Inflammation 323 97.96 Very High Very High Very High
Multiple sclerosis 38 88.32 High High
Inflammatory mediators 19 78.20 Quite High
Disease Link Frequency Relevance Heat
Death 223 99.96 Very High Very High Very High
Ocular Hypertension 564 99.90 Very High Very High Very High
Retina Disease 55 99.82 Very High Very High Very High
Optic Neuritis 21 99.68 Very High Very High Very High
Blindness 45 99.56 Very High Very High Very High
Glaucoma 761 99.50 Very High Very High Very High
Disease 83 99.42 Very High Very High Very High
Optic Nerve Injuries 16 98.66 Very High Very High Very High
INFLAMMATION 361 97.96 Very High Very High Very High
Ganglion Cysts 242 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After treatment was stopped on day 14, mice rapidly developed EAE and optic neuritis by day 18, but RGC loss was still reduced.
Negative_regulation (loss) of RGC in optic
1) Confidence 0.51 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19892867 Disease Relevance 0.14 Pain Relevance 0
Here the authors examined whether corticosteroids administered early in the disease course can prevent RGC loss in experimental optic neuritis.
Negative_regulation (loss) of RGC in optic associated with corticosteroid, optic neuritis, disease and neuritis
2) Confidence 0.51 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 19892867 Disease Relevance 0.61 Pain Relevance 0.39
In the few eyes that developed optic neuritis, inflammation was mild, and RGC loss was attenuated.
Negative_regulation (loss) of RGC in eyes
3) Confidence 0.43 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19892867 Disease Relevance 0.15 Pain Relevance 0
CONCLUSIONS: Corticosteroids can suppress optic neuritis and prevent RGC loss if treatment is initiated before optic nerve inflammation onset.
Negative_regulation (loss) of RGC in optic
4) Confidence 0.37 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19892867 Disease Relevance 0.11 Pain Relevance 0
By day 22, RGC loss increased to levels similar to those of untreated optic neuritis eyes.
Negative_regulation (loss) of RGC in eyes
5) Confidence 0.37 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19892867 Disease Relevance 0.14 Pain Relevance 0
Corticosteroid treatment after optic neuritis onset (days 10-14) slowed EAE progression and showed a trend toward suppression of optic neuritis and RGC loss on day 14 that was lost by day 18.
Negative_regulation (suppression) of RGC in RGC
6) Confidence 0.37 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19892867 Disease Relevance 0.12 Pain Relevance 0
Corticosteroid treatment after optic neuritis onset (days 10-14) slowed EAE progression and showed a trend toward suppression of optic neuritis and RGC loss on day 14 that was lost by day 18.
Negative_regulation (loss) of RGC in RGC
7) Confidence 0.37 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19892867 Disease Relevance 0.12 Pain Relevance 0
In vivo, exogenous TNF leads to loss of oligodendrocytes and a delayed loss of RGC.
Negative_regulation (loss) of RGC in oligodendrocytes
8) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.92 Pain Relevance 0.07
This loss of RGC appeared to worsen at 15 months of age (Figure 1C).
Negative_regulation (loss) of RGC
9) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.29 Pain Relevance 0
Glaucoma, the second leading causes of blindness, is characterized by loss of RGC and excavation of the optic nerve head [12].
Negative_regulation (loss) of RGC in optic nerve head associated with blindness and glaucoma
10) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.39 Pain Relevance 0.24
Significant loss of RGC was observed in flat whole-mount retina from DBA/2J mice at 6 months of age (Figure 1B) in comparison to age-matched control C57BL/6J mice (Figure 1D).
Negative_regulation (loss) of RGC in retina
11) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.17 Pain Relevance 0
Furthermore, a functional blockade of TNF with TNF blocking antibody or deletion of the gene encoding TNF completely prevents ocular hypertension-induced oligodendrocyte degeneration and the secondary loss of RGC [44].
Negative_regulation (loss) of RGC in oligodendrocyte associated with ocular hypertension
12) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.26 Pain Relevance 0.17
These findings indicate that PEDF potently and efficaciously reduces RGC loss in DBA/2J mice, reduces expression of TNF and IL-18, and downregulates GFAP.
Negative_regulation (loss) of RGC
13) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.81 Pain Relevance 0.07
Loss of RGC was apparent in DBA/2J mice at 6 months, and appeared to have dramatically worsened at 15 months of age (Figures 1F,G, respectively), as compared with retina from C57BL/6J mice (Figure 1H).


Negative_regulation (Loss) of RGC in retina
14) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.37 Pain Relevance 0
The BDNF gene transferred into RGC by electroporation or BDNF injected into the SC could prevent RGC loss after axotomy [54,55].
Negative_regulation (loss) of RGC
15) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.40 Pain Relevance 0
Moreover, a functional blockade of TNF with a TNF blocking antibody or deletion of the gene encoding TNF in mice completely prevented ocular hypertension-induced oligodendrocyte degeneration and the secondary loss of RGC.
Negative_regulation (loss) of RGC in oligodendrocyte associated with ocular hypertension
16) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.65 Pain Relevance 0.13
Our results support a role for PEDF as a potent and efficacious agent to reduce RGC death and vision loss in DBA/2J mice.
Negative_regulation (reduce) of RGC associated with death
17) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.19 Pain Relevance 0.15
In order to suppress RGC activity, we injected tetrodotoxin (TTX) into one eye from P10 to P14.
Negative_regulation (suppress) of RGC in eye associated with tetrodotoxin
18) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0.08 Pain Relevance 0.45
We have previously reported that IL-18 gene expression in the iris/ciliary body and IL-18 protein in the aqueous humor of DBA/2J mice are significantly increased, and further demonstrated that these increases occur before the development of elevated IOP and loss of RGC [21].
Negative_regulation (loss) of RGC in iris associated with ocular hypertension
19) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.29 Pain Relevance 0.06
It has been suggested that lower levels of PEDF in aqueous humor of eyes with neuroretinal dystrophy – including those with advanced glaucoma – may be related to the loss of the RGC or pigment epithelium cells that synthesize PEDF [8,22].
Negative_regulation (loss) of RGC in epithelium associated with glaucoma
20) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.15 Pain Relevance 0.08

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