INT164117

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.16
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (1190002H23Rik) nucleus (1190002H23Rik) cell cycle (1190002H23Rik)
cytoplasm (1190002H23Rik)
Anatomy Link Frequency
eyes 2
neurons 2
RGC 2
1190002H23Rik (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 6 99.98 Very High Very High Very High
withdrawal 1 98.88 Very High Very High Very High
Glutamate 2 98.26 Very High Very High Very High
Inflammation 17 93.76 High High
corticosteroid 3 50.00 Quite Low
Neuritis 3 50.00 Quite Low
Inflammatory mediators 1 6.00 Low Low
anesthesia 7 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retina Disease 4 99.98 Very High Very High Very High
Ganglion Cysts 22 97.72 Very High Very High Very High
INFLAMMATION 19 93.76 High High
Apoptosis 2 89.92 High High
Diabetic Retinopathy 3 87.20 High High
Ocular Hypertension 111 84.48 Quite High
Death 19 80.36 Quite High
Injury 15 74.20 Quite High
Glaucoma 50 71.52 Quite High
Optic Nerve Injuries 4 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By day 22, RGC loss increased to levels similar to those of untreated optic neuritis eyes.
Positive_regulation (increased) of Negative_regulation (loss) of RGC in eyes
1) Confidence 0.40 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19892867 Disease Relevance 0.14 Pain Relevance 0
PEDF has also been shown to protect adult rat retinal ganglion cells (RGC) from glutamate- and trophic factor withdrawal-mediated cytotoxicity [7], and reduce retinal ischemia-induced RGC loss [8,9].
Positive_regulation (induced) of Negative_regulation (loss) of RGC in RGC associated with ganglion cysts, glutamate, ischemia, withdrawal and retina disease
2) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.24 Pain Relevance 0.27
Progressive loss of RGCs was observed when these neurons were identified with Brn3a immunofluorescence, which agrees with previous studies of RGC loss induced by an axotomy-like insult, such as ON transection [93], ON crush [74,94], or axon bundle ligation [71,83-86].


Positive_regulation (induced) of Negative_regulation (loss) of RGC in neurons
3) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.79 Pain Relevance 0

General Comments

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