INT164125

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.15
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TRPM2) transmembrane transport (TRPM2)
Anatomy Link Frequency
neutrophils 1
TRPM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 2 97.72 Very High Very High Very High
TRP channel 8 89.88 High High
Inflammation 8 67.20 Quite High
member 8 2 47.28 Quite Low
agonist 7 17.68 Low Low
addiction 5 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 84.32 Quite High
INFLAMMATION 11 67.20 Quite High
Toxicity 1 37.76 Quite Low
Pneumonia 1 32.56 Quite Low
Attention Deficit Hyperactivity Disorder 1 9.52 Low Low
Disease 5 6.24 Low Low
Neutrophil Disorders 2 5.56 Low Low
Adhesions 5 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Pulmonary Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The contribution of TRPM2 to Ca(2+) influx in neutrophils strongly depends on the stimulus; it is sizeable in the case of fMLP and minimal in the case of PAF.
TRPM2 Binding (contribution) of in neutrophils
1) Confidence 0.36 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 19894037 Disease Relevance 0 Pain Relevance 0.07
For TRPM2, co-immunoprecipitation experiments demonstrated CaM1234 binding to the channel, indicating that Ca2+-independent CaM binding contributes to the facilitation mechanism.
TRPM2 Binding (binding) of
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.09
The non-selective cation channel TRPM2, a member of the TRP family, is recognized to have an oxidative sensitivity and be positively regulated by H2O2.
TRPM2 Binding (recognized) of
3) Confidence 0.20 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.15 Pain Relevance 0.03
The average annual winter home range size in SSR is 195 km2 compared with 331 km2 for its summer counterpart in KNP and, as can be expected, the home range increases with the time the elephant spends in each reserve (r?
KNP Binding (counterpart) of
4) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2587706 Disease Relevance 0 Pain Relevance 0

General Comments

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