INT164144

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.15
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
neurite 1
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antinociception 10 99.16 Very High Very High Very High
Inflammation 79 96.56 Very High Very High Very High
gABA 11 94.08 High High
Hyperalgesia 8 88.84 High High
GABA receptor 10 80.32 Quite High
Pain 4 75.00 Quite High
Neuropathic pain 19 73.76 Quite High
Spinal cord 1 62.24 Quite High
Antinociceptive 6 60.00 Quite High
antagonist 15 50.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 91 96.56 Very High Very High Very High
Hyperalgesia 9 88.84 High High
Increased Venous Pressure Under Development 10 86.80 High High
Nociception 4 80.56 Quite High
Neuropathic Pain 29 75.00 Quite High
Reprotox - General 2 4 55.60 Quite High
Pulmonary Disease 62 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Hypertension 10 5.00 Very Low Very Low Very Low
Vomiting 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of phosphodiesterase 5 produces an antinociception through the increase of cyclic guanosine monophosphate (cGMP), and increasing cGMP levels enhance the release of ?
Phosphorylation (monophosphate) of cGMP associated with antinociception
1) Confidence 0.19 Published 2010 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2799976 Disease Relevance 0.35 Pain Relevance 0.48
PDE5 exists as a homodimer, and as well as the conserved catalytic site, it contains highly cGMP-specific allosteric (non-catalytic) cGMP-binding sites and a phosphorylation site in the N-terminal domain (Corbin and Francis 1999).
Phosphorylation (phosphorylation) of cGMP
2) Confidence 0.17 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.05 Pain Relevance 0
PDE5 exists as a homodimer, and as well as the conserved catalytic site, it contains highly cGMP-specific allosteric (non-catalytic) cGMP-binding sites and a phosphorylation site in the N-terminal domain (Corbin and Francis 1999).
Phosphorylation (phosphorylation) of cGMP
3) Confidence 0.17 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.06 Pain Relevance 0
In primary neurons from rats, treatment with the PKG-I activator 8-Br-cGMP induced a time-dependent phosphorylation of cofilin and significantly increased neurite outgrowth.
Phosphorylation (phosphorylation) of cGMP in neurite
4) Confidence 0.10 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19896457 Disease Relevance 0.68 Pain Relevance 0.39

General Comments

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