INT164152

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.41
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (PSMD2) cytosol (PSMD2) nucleoplasm (PSMD2)
small molecule metabolic process (PSMD2) cellular nitrogen compound metabolic process (PSMD2)
Anatomy Link Frequency
heart 1
STG 1
PSMD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 4 99.76 Very High Very High Very High
insula 3 99.20 Very High Very High Very High
Glutamate 2 94.24 High High
addiction 83 92.64 High High
Somatosensory cortex 1 89.76 High High
Pain 10 87.20 High High
depression 6 75.00 Quite High
imagery 2 69.72 Quite High
isoflurane 1 60.88 Quite High
anesthesia 1 60.00 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 20 99.68 Very High Very High Very High
Li-fraumeni Syndrome 10 99.36 Very High Very High Very High
Myocardial Infarction 12 99.26 Very High Very High Very High
Phenylketonuria 4 95.48 Very High Very High Very High
Pain 10 87.20 High High
Fever 79 86.60 High High
Syndrome 35 85.68 High High
Infection 5 79.32 Quite High
Depression 6 75.00 Quite High
Hypertension 28 73.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A diminished S2, therefore, would result due to the more slowly developing driving pressure, which directly affects the characteristics of valvular vibration.
Negative_regulation (diminished) of S2
1) Confidence 0.37 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2531180 Disease Relevance 0.15 Pain Relevance 0
But patients suffering from myocardial infarction and/or heart failure, often exhibit reduced S2 amplitude, even when the aortic pressure is normal [18].
Negative_regulation (reduced) of S2 in heart associated with heart rate under development and myocardial infarction
2) Confidence 0.36 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2531180 Disease Relevance 0.32 Pain Relevance 0
Obviously, sensor measured S2 amplitude, without ventricular relaxation hemodynamics, cannot sense the ventricular component of the S2.
Negative_regulation (measured) of S2
3) Confidence 0.36 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2531180 Disease Relevance 0.12 Pain Relevance 0
When LV relaxation was impaired, increasing T greater than 135% of control, the S2 intensity for any given aortic pressure was reduced.
Negative_regulation (reduced) of S2
4) Confidence 0.36 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2531180 Disease Relevance 0.11 Pain Relevance 0
Contrast between Pre and Post LFS indicated significant activity decrease in bilateral S1,S2, and ACC and right insula, IPL, and STG.
Negative_regulation (decrease) of S2 in STG associated with li-fraumeni syndrome, insula and anterior cingulate cortex
5) Confidence 0.29 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19896873 Disease Relevance 1.78 Pain Relevance 1.04
Data are presented in Figure 1, Figure 2 and Additional File 3, Table S2.
Negative_regulation (presented) of S2
6) Confidence 0.14 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.71 Pain Relevance 0.03
A description of the database statistics is given in Table S1, and the functional annotation fields are listed in Table S2.
Negative_regulation (listed) of S2
7) Confidence 0.07 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2174978 Disease Relevance 0.22 Pain Relevance 0.33
With the occurrence in Nav1.4 of neutral Asn at what would be the outermost anionic site of S2 (D2N608 and D4N1382) what becomes of the electrostatic interactions?
Negative_regulation (site) of S2
8) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766034 Disease Relevance 0 Pain Relevance 0.08
l at four sites/rat), or aged GnRH analogs (i.e., S2 and S4; 200 ?
Negative_regulation (aged) of S2
9) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225439 Disease Relevance 0 Pain Relevance 0.09

General Comments

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