INT164160

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.39
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDH1) cell adhesion (CDH1) Golgi apparatus (CDH1)
plasma membrane (CDH1) cytoplasm (CDH1)
Anatomy Link Frequency
muscle tissue 1
epithelial cells 1
neural 1
CDH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1 70.84 Quite High
nud 1 68.96 Quite High
abdominal pain 1 68.44 Quite High
cytokine 11 49.36 Quite Low
Inflammation 28 46.80 Quite Low
cva 15 5.00 Very Low Very Low Very Low
headache 9 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 14 98.36 Very High Very High Very High
Cancer 260 98.04 Very High Very High Very High
Celiac Disease 58 97.94 Very High Very High Very High
Adhesions 19 95.24 Very High Very High Very High
Metastasis 54 92.20 High High
Disease 82 92.12 High High
Apoptosis 1 89.40 High High
Hyperplasia 2 87.72 High High
Meningioma 9 84.16 Quite High
Enteropathy 5 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These changes are accompanied by a re-localization of the expression patterns of E-cadherin and catenins.
Localization (localization) of E-cadherin
1) Confidence 0.66 Published 2010 Journal J Ethnopharmacol Section Abstract Doc Link 19897022 Disease Relevance 0.94 Pain Relevance 0.10
As indicated, this protein works as an E-cadherin-gene repressor, required for triggering EMT.
Localization (required) of E-cadherin-gene repressor
2) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.84 Pain Relevance 0.04
Cell cultures were tested at 1–1.5 weeks post-confluency for the presence of cytokeratins, vimentin, connexin43, desmoplakins 1&2, E-cadherin, and ZO-1.
Localization (presence) of E-cadherin
3) Confidence 0.29 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0 Pain Relevance 0
Several types have been described, including N-cadherin in neural and muscle tissue, P-cadherin in placental tissue, E-cadherin found in epithelial cells, and VE-cadherin expressed exclusively in endothelial cells [47,48].
Localization (found) of E-cadherin in neural
4) Confidence 0.29 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.27 Pain Relevance 0
E12 (M0630, 1:100, 1 hr; Dako, Mississauga, ON), mouse monoclonal Vimentin (Vim3B4, 1:200, 1 hr; American Research Products, Belmont, MA), mouse monoclonal E-cadherin (36B5, 1:100, overnight; Vector Labs, Burlington, ON), mouse monoclonal p63(7JUL, 1:50, 2 hrs; Vector Labs) and human cytokeratin cocktail (AE1/AE3, 1:200, 1 hr; Dako).
Localization (monoclonal) of E-cadherin
5) Confidence 0.26 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.10 Pain Relevance 0
Figure 6A and 6B demonstrate that normal pancreas samples contain abundant E-cadherin expressing epithelial cells, as expected, while tumor samples contain a high proportion of ?
Localization (abundant) of E-cadherin in epithelial cells associated with cancer
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.52 Pain Relevance 0
Several types have been described, including N-cadherin in neural and muscle tissue, P-cadherin in placental tissue, E-cadherin found in epithelial cells, and VE-cadherin expressed exclusively in endothelial cells [47,48].
Localization (found) of E-cadherin in muscle tissue
7) Confidence 0.10 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.27 Pain Relevance 0
Moreover, the jejunal tight junction structure is morphologically altered in celiac sprue patients [81], and molecular analysis of these junctions has recently revealed that both occludin and E-cadherin fail to localize properly [82].
Localization (localize) of E-cadherin associated with celiac disease
8) Confidence 0.03 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.44 Pain Relevance 0

General Comments

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