INT164171

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 12.45
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cd163) plasma membrane (Cd163)
Anatomy Link Frequency
macrophages 12
monocytes 1
synovial cells 1
vessels 1
PMNs 1
Cd163 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 913 99.68 Very High Very High Very High
Inflammation 414 99.66 Very High Very High Very High
cytokine 99 99.00 Very High Very High Very High
Infliximab 52 94.16 High High
Arthritis 274 79.28 Quite High
Etanercept 4 71.40 Quite High
Adalimumab 4 69.44 Quite High
methotrexate 14 65.08 Quite High
cINOD 28 60.56 Quite High
spinal inflammation 83 53.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 389 99.92 Very High Very High Very High
Rheumatoid Arthritis 913 99.68 Very High Very High Very High
Hyperplasia 54 99.28 Very High Very High Very High
Disease 570 98.76 Very High Very High Very High
Myositis 108 96.16 Very High Very High Very High
Arthritis 204 94.94 High High
Synovitis 106 89.44 High High
Targeted Disruption 12 85.92 High High
Dermatomyositis 44 78.76 Quite High
Polymyositis 40 77.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in more detail in Table 3 (top), lining-layer thickness, sublining CD68, and sublining CD163 were weakly but significantly correlated with the SJC in SpA.
Gene_expression (sublining) of CD163
1) Confidence 0.49 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 0.73 Pain Relevance 0.19
The remaining eight biopsies were embedded in tissue-freezing medium and used for immunohistochemistry with the following antibodies: anti-CD1a (interdigitating dendritic cells, mouse, monoclonal; Dako, Glostrup, Denmark), anti-CD3 (T cells, mouse, monoclonal; Dako), anti-CD20 (B cells, mouse, monoclonal; Dako), anti-CD68 (monocytes and macrophages, mouse, monoclonal, clone EBM11; Dako), anti-CD163 (scavenger receptor expressed on mature tissue macrophages, mouse, monoclonal, clone Ber-MAC3; Dako), anti-L-citrulline (citrullinated peptides, rabbit, polyclonal; Biogenesis, Poole, UK), and mAb 12A (detecting MHC class II–HC gp39 peptide complexes, mouse, monoclonal; NV Organon, Oss, Netherlands).
Gene_expression (expressed) of CD163 in macrophages
2) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 0 Pain Relevance 0
In conclusion, these data indicate that inflammatory infiltration of the synovium with CD163+ macrophages and PMNs as well as lining-layer hyperplasia reflect global disease activity in SpA, independently of the SpA subtype.
Gene_expression (macrophages) of CD163 in PMNs associated with inflammation, disease and hyperplasia
3) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065336 Disease Relevance 1.03 Pain Relevance 0.12
Both classical statistics and SAM analysis demonstrated a correlation with lining-layer hyperplasia and, more consistently, inflammatory infiltration by CD163+ macrophages and PMNs.
Gene_expression (macrophages) of CD163 in macrophages associated with inflammation and hyperplasia
4) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.22 Pain Relevance 0.21
Despite the fact that lining-layer hyperplasia and inflammatory infiltration with CD163+ macrophages and PMNs reflected the global disease activity when cohorts of patients were analyzed, multiparameter models based on synovial histopathology turned out to be relatively poor predictors of disease severity in individual patients.
Gene_expression (macrophages) of CD163 in macrophages associated with inflammation, disease and hyperplasia
5) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.18 Pain Relevance 0.19
RI expression after local glucocorticoid injection was not due to a reduced number of macrophages in the tissue, as no significant difference in CD163 expression was found after treatment.
Gene_expression (expression) of CD163 in macrophages
6) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206344 Disease Relevance 0.95 Pain Relevance 0.40
RI, II and III expression was significantly correlated with CD163 expression in the RA synovia (Fc?
Gene_expression (expression) of CD163 associated with rheumatoid arthritis
7) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206344 Disease Relevance 0.74 Pain Relevance 0.37
Several clues for the linkage between gut and joint inflammation have been put forward including an altered recognition and handling of bacterial antigens, an aberrant trafficking of CD8+ T cells with an impaired T-helper type 1 cytokine profile and expression of aEb7 integrin, an altered trafficking of macrophages expressing CD163 and evidence of an increased angiogenesis.
Gene_expression (expressing) of CD163 in T cells associated with inflammation, arthritis and cytokine
8) Confidence 0.34 Published 2009 Journal Dig Dis Section Abstract Doc Link 19897967 Disease Relevance 1.34 Pain Relevance 0.74
The CD163 antigen is known to be exclusively expressed by mature peripheral blood monocytes and macrophages [32,33].
Gene_expression (expressed) of CD163 in macrophages
9) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206344 Disease Relevance 0 Pain Relevance 0.03
The presence of CD163 positive macrophages was also investigated before and after glucocorticoid treatment but no difference in CD163 expression was found.
Gene_expression (expression) of CD163 in macrophages
10) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206344 Disease Relevance 0.75 Pain Relevance 0.31
Moreover, consecutive DAB stained slides of CD163 positive macrophages and Fc?
Gene_expression (positive) of CD163 in macrophages
11) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206344 Disease Relevance 0.70 Pain Relevance 0.35
RIII revealed by DAB staining was significantly correlated with the expression of the macrophage marker CD163.
Gene_expression (expression) of CD163 in macrophage
12) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206344 Disease Relevance 0.59 Pain Relevance 0.31
It is tempting to speculate that the population of CD68 cells that decreased as a result of the treatment constitutes cells that did not express CD163 or mPGES-1, as these molecules were not changed after treatment.
Neg (not) Gene_expression (express) of CD163
13) Confidence 0.28 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.29 Pain Relevance 0.11
Double immunofluorescence revealed the expression of mPGES-1 in CD163-positive (fig 4A–C) and of CD68-positive macrophages (data not shown).
Gene_expression (expression) of CD163 in macrophages
14) Confidence 0.24 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.62 Pain Relevance 0.11
Positive staining for CD3, CD68 and CD163 markers was detected in infiltrates, in scattered cells and in cells surrounding large vessels.
Gene_expression (staining) of CD163 in vessels
15) Confidence 0.24 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.37 Pain Relevance 0.05
Expression of CD3, CD68 and CD163 was assessed quantitatively using computer-assisted image analysis.
Gene_expression (Expression) of CD163
16) Confidence 0.22 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.07 Pain Relevance 0.04
Double immunofluorescence staining, performed for two of the patients, revealed co-expression between IL-15, analysed with the neutralizing antibody, and CD163 (macrophages) (Figure 2).
Gene_expression (expression) of CD163 in macrophages
17) Confidence 0.21 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0 Pain Relevance 0.23
Synovial cellularity was decreased after 8 to 10 weeks of treatment with a significant reduction of the CD68-positive synovial cells, whereas no significant change was seen in the number of CD3-positive T cells and CD163-expressing macrophages.
Gene_expression (expressing) of CD163 in synovial cells
18) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526582 Disease Relevance 0.55 Pain Relevance 0.35
Further, we found a co-expression of IL-15 and CD163 when analysed with double staining, indicating that IL-15 in the RA synovial membrane is predominantly produced by macrophages.
Gene_expression (expression) of CD163 in macrophages associated with rheumatoid arthritis
19) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.31 Pain Relevance 0.39
In conclusion, these data indicate that inflammatory infiltration of the synovium with CD163+ macrophages and PMNs as well as lining-layer hyperplasia reflect global disease activity in SpA, independently of the SpA subtype.
Gene_expression (macrophages) of CD163 in macrophages associated with inflammation, disease and hyperplasia
20) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065336 Disease Relevance 1.03 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox