INT164173

Context Info Confidence 0.00 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.32 Pain Relevance 0.77

cell adhesion (ITGB7) plasma membrane (ITGB7)

Anatomy Link Frequency T cells 2 ITGB7 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 1 99.74 Inflammation 9 96.28 Etanercept 1 74.08 Adalimumab 1 72.12 Infliximab 1 71.52 methotrexate 1 67.76 Arthritis 5 67.20 cINOD 2 63.24 spinal inflammation 5 56.20 backache 1 54.40

Disease Link Frequency Relevance Heat Arthritis 9 96.28 Targeted Disruption 1 88.60 INFLAMMATION 4 83.16 Recurrence 1 77.28 Enteropathy 1 76.96 Inflammatory Bowel Disease 5 75.00 Disease 3 72.88 Low Back Pain 6 56.20 Sacroiliitis 1 54.96 Arthropathy 1 53.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Several clues for the linkage between gut and joint inflammation have been put forward including an altered recognition and handling of bacterial antigens, an aberrant trafficking of CD8+ T cells with an impaired T-helper type 1 cytokine profile and expression of aEb7 integrin, an altered trafficking of macrophages expressing CD163 and evidence of an increased angiogenesis.

Regulation (altered) of Gene_expression (expression) of aEb7 integrin in T cells associated with inflammation, arthritis and cytokine

1) Confidence 0.00 Published 2009 Journal Dig Dis Section Abstract Doc Link 19897967 Disease Relevance 1.32 Pain Relevance 0.77

General Comments

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