INT164173

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.32
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB7) plasma membrane (ITGB7)
Anatomy Link Frequency
T cells 2
ITGB7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1 99.74 Very High Very High Very High
Inflammation 9 96.28 Very High Very High Very High
Etanercept 1 74.08 Quite High
Adalimumab 1 72.12 Quite High
Infliximab 1 71.52 Quite High
methotrexate 1 67.76 Quite High
Arthritis 5 67.20 Quite High
cINOD 2 63.24 Quite High
spinal inflammation 5 56.20 Quite High
backache 1 54.40 Quite High
Disease Link Frequency Relevance Heat
Arthritis 9 96.28 Very High Very High Very High
Targeted Disruption 1 88.60 High High
INFLAMMATION 4 83.16 Quite High
Recurrence 1 77.28 Quite High
Enteropathy 1 76.96 Quite High
Inflammatory Bowel Disease 5 75.00 Quite High
Disease 3 72.88 Quite High
Low Back Pain 6 56.20 Quite High
Sacroiliitis 1 54.96 Quite High
Arthropathy 1 53.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several clues for the linkage between gut and joint inflammation have been put forward including an altered recognition and handling of bacterial antigens, an aberrant trafficking of CD8+ T cells with an impaired T-helper type 1 cytokine profile and expression of aEb7 integrin, an altered trafficking of macrophages expressing CD163 and evidence of an increased angiogenesis.
Regulation (altered) of Gene_expression (expression) of aEb7 integrin in T cells associated with inflammation, arthritis and cytokine
1) Confidence 0.00 Published 2009 Journal Dig Dis Section Abstract Doc Link 19897967 Disease Relevance 1.32 Pain Relevance 0.77

General Comments

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