INT164189

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 82
Total Number 97
Disease Relevance 60.77
Pain Relevance 5.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TREM1) plasma membrane (TREM1) intracellular (TREM1)
Anatomy Link Frequency
monocytes 17
myeloid cells 8
neutrophils 8
alveolar macrophages 4
NK cells 4
TREM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 914 99.76 Very High Very High Very High
Potency 9 99.58 Very High Very High Very High
Inflammatory response 154 98.08 Very High Very High Very High
chemokine 72 97.76 Very High Very High Very High
agonist 104 97.60 Very High Very High Very High
cytokine 239 93.84 High High
Inflammatory mediators 132 87.60 High High
peptic ulcer disease 38 87.32 High High
imagery 60 82.76 Quite High
cva 99 70.84 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Disease 1528 100.00 Very High Very High Very High
INFLAMMATION 1146 99.76 Very High Very High Very High
Sepsis 901 99.34 Very High Very High Very High
Infection 763 99.16 Very High Very High Very High
Pneumonia 1038 99.14 Very High Very High Very High
Syndrome 105 99.00 Very High Very High Very High
Disease 752 98.80 Very High Very High Very High
Critical Illness 104 98.80 Very High Very High Very High
Hemophilus Infection 84 98.76 Very High Very High Very High
Pulmonary Alveolar Proteinosis 525 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No significant correlations were found between APACHE II scores and expression of TREM-1 on neutrophils on day 1 as well as between SOFA scores and any of the measured parameters on day 1.
Gene_expression (expression) of TREM-1 in neutrophils
1) Confidence 0.62 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.35 Pain Relevance 0
Comparisons between groups for nTREM-1, mTREM-1 expression and for CRP were done by ANOVA, followed by the Tukey's test for multiple comparisons.
Gene_expression (expression) of nTREM-1
2) Confidence 0.62 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0 Pain Relevance 0
Positive correlations were found between APACHE II scores and expression of TREM-1 on monocytes on day 1 (rs: +0.363, p: 0.010); and between APACHE II scores and sTREM-1 on day 1 (rs: +0.262, p: 0.043).
Gene_expression (expression) of TREM-1 in monocytes
3) Confidence 0.62 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.22 Pain Relevance 0
Concentrations of sTREM-1 and of CRP in sera of both groups and expression of nTREM-1 and mTREM-1 are given in Table 2.
Gene_expression (expression) of nTREM-1
4) Confidence 0.62 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.91 Pain Relevance 0.06
The results of our study are in contrast to those of another study [37] that did not disclose any difference in nTREM-1 expression between patients with and without a bacterial lung infection probably due to the small number of patients included in that former study.
Gene_expression (expression) of nTREM-1 in lung associated with infection
5) Confidence 0.62 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.71 Pain Relevance 0.16
Three ml were collected into EDTA-coated tubes (Vacutainer, BD) for estimation of nTREM-1 and mTREM-1 expression.
Gene_expression (expression) of nTREM-1 in tubes
6) Confidence 0.62 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.44 Pain Relevance 0.05
Correlations between serum levels of sTREM-1 and CRP and expression of TREM-1 on monocytes and neutrophils in relation to the identified causative pathogen of CAP are shown in Figure 3.
Gene_expression (expression) of TREM-1 in neutrophils associated with pneumonia
7) Confidence 0.62 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.43 Pain Relevance 0
Correlations between serum levels of sTREM-1 and CRP and expression of TREM-1 on monocytes and neutrophils in relation to the identified causative pathogen of CAP are shown in Figure 3.
Gene_expression (expression) of sTREM-1 in neutrophils associated with pneumonia
8) Confidence 0.62 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.42 Pain Relevance 0
soluble TREM-1 (sTREM-1) are detectable in bronchoalveolar lavage (BAL) fluid
Gene_expression (detectable) of soluble TREM-1
9) Confidence 0.58 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.05 Pain Relevance 0.11
For the detection of soluble TREM-1 (sTREM-1), anti-TREM-1 (6B1) mAb was coated at 0.5 ?
Gene_expression (detection) of soluble TREM-1
10) Confidence 0.58 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.08 Pain Relevance 0
For the detection of soluble TREM-1 (sTREM-1), anti-TREM-1 (6B1) mAb was coated at 0.5 ?
Gene_expression (detection) of sTREM-1
11) Confidence 0.58 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.08 Pain Relevance 0
soluble TREM-1 (sTREM-1) are detectable in bronchoalveolar lavage (BAL) fluid
Gene_expression (detectable) of sTREM-1
12) Confidence 0.58 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.04 Pain Relevance 0.11
Levels of sTREM-1 in serum were correlated with absolute FEV1 (r=?
Gene_expression (Levels) of sTREM-1
13) Confidence 0.58 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.50 Pain Relevance 0
ELISA assay could be the reason for increased levels of sTREM-1 detected in the
Gene_expression (levels) of sTREM-1
14) Confidence 0.58 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.09 Pain Relevance 0.20
Also levels of sTREM-1 in serum were
Gene_expression (levels) of sTREM-1
15) Confidence 0.58 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.23 Pain Relevance 0.17
increased levels of sTREM-1 in serum.
Gene_expression (levels) of sTREM-1
16) Confidence 0.58 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.18 Pain Relevance 0.16
Positive correlations were found between APACHE II scores and expression of TREM-1 on monocytes on day 1 (rs: +0.363, p: 0.010); and between APACHE II scores and sTREM-1 on day 1 (rs: +0.262, p: 0.043).
Gene_expression (expression) of sTREM-1 in monocytes
17) Confidence 0.54 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.35 Pain Relevance 0
For the measurement of sTREM-1, mTREM-1, nTREM-1 and CRP 10 ml of peripheral venous blood were sampled after venipuncture of the antecubitul vein under sterile conditions on the day of admission and on days 3 and 7 of hospitalization.
Gene_expression (measurement) of sTREM-1 in blood
18) Confidence 0.54 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.90 Pain Relevance 0.07
For the measurement of sTREM-1, mTREM-1, nTREM-1 and CRP 10 ml of peripheral venous blood were sampled after venipuncture of the antecubitul vein under sterile conditions on the day of admission and on days 3 and 7 of hospitalization.
Gene_expression (measurement) of nTREM-1 in blood
19) Confidence 0.54 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.90 Pain Relevance 0.07
White blood cells were labelled by phycoerythrin-conjugated anti-TREM-1 monoclonal antibodies (R&D InC, Minneapolis, USA) for 30 minutes in the dark. nTREM-1 and mTREM-1 expression were assessed after passage of labelled cells through a flow cytometer (Epics XL/MSL, Beckman-Coulter Co, Miami Florida) and expressed as the mean fluorescence intensity (MFI) with gating for neutrophils and for monocytes by their characteristic FS/SS scattering.
Gene_expression (expressed) of nTREM-1 in White blood cells
20) Confidence 0.54 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.24 Pain Relevance 0

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