INT164192

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.51
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SLPI) enzyme binding (SLPI)
Anatomy Link Frequency
leukocyte 2
myeloid cells 1
SLPI (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 30 94.72 High High
spastic colon 1 92.00 High High
Crohn's disease 20 81.84 Quite High
metalloproteinase 3 42.24 Quite Low
tolerance 5 29.04 Quite Low
cytokine 5 5.88 Low Low
Bile 6 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 67 99.02 Very High Very High Very High
INFLAMMATION 27 94.72 High High
Functional Bowel Disorder 1 92.00 High High
Disorder Of Lipid Metabolism 6 85.56 High High
Disease 42 81.20 Quite High
Metaplasia 3 75.84 Quite High
Cancer 42 73.48 Quite High
Pancreatic Cancer 27 66.08 Quite High
Inflammatory Bowel Disease 20 64.08 Quite High
Insulin Resistance 20 56.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALK) were also measured.


Localization (measured) of ALK
1) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 0.22 Pain Relevance 0
Included among these were transcripts for a group of 20 genes, such as interleukin-1 (IL-1) receptors 1 and 2, Nod-like receptor family, pyrin domain containing 2 (NLRP2), secretory leukocyte peptidase inhibitor (SLPI), secreted protein acidic and rich in cysteine (SPARC), and triggering receptor expressed on myeloid cells 1 (TREM-1) that are clearly related to the immune or inflammatory response and a group of 4 transcripts that have a strong role in bone remodeling.
Localization (secreted) of SLPI in myeloid cells
2) Confidence 0.44 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19900269 Disease Relevance 0 Pain Relevance 0
-defensin, LL37 and secreted leukocyte protease inhibitor.
Localization (secreted) of leukocyte protease in leukocyte
3) Confidence 0.38 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.68 Pain Relevance 0.32
These genes include many not previously associated with pancreatic adenocarcinoma, such as galectin-4 (LGALS4), mucin 13 (MUC13), secretory leukocyte protease inhibitor (SLPI), collagen 17A1 (COL17A1), and ropporin 1-like (ROPN1L).
Localization (secretory) of leukocyte protease in leukocyte associated with adenocarcinoma
4) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 0.61 Pain Relevance 0

General Comments

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