INT164196

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.59
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LRP1) endosome (LRP1) aging (LRP1)
plasma membrane (LRP1) nucleus (LRP1) cytoplasm (LRP1)
Anatomy Link Frequency
macrophages 1
leg 1
LRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 2 99.64 Very High Very High Very High
Inflammation 18 97.68 Very High Very High Very High
cva 1 91.12 High High
anesthesia 1 86.12 High High
rheumatoid arthritis 56 73.76 Quite High
antagonist 7 51.16 Quite High
cryotherapy 14 5.00 Very Low Very Low Very Low
cINOD 13 5.00 Very Low Very Low Very Low
methotrexate 9 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 15 99.46 Very High Very High Very High
Reprotox - General 1 1 98.08 Very High Very High Very High
Compartment Syndromes 4 97.16 Very High Very High Very High
Obesity 1 95.84 Very High Very High Very High
Increased Venous Pressure Under Development 1 95.00 High High
Prostate Cancer 71 94.16 High High
Hypertension 1 93.28 High High
Hyperlipidemia 1 92.72 High High
Diabetes Mellitus 3 91.92 High High
Cv General 3 Under Development 1 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are several circumstantial risk factors associated with LRP that, when combined, may potentially predispose to the development of compartment syndrome, including: obesity, evidence of peripheral vascular disease (advanced age, hypertension, hyperlipidemia, and diabetes mellitus), thromboembolism prophylaxis with compressive leg wraps together with intermittent pneumatic devices, combined general-spinal anesthesia, prolonged operative time in Trendelenburg position, and systemic hypotension due to intraoperative bleeding.
LRP Binding (associated) of in leg associated with anesthesia, diabetes mellitus, hemorrhage, increased venous pressure under development, compartment syndromes, pressure volume 2 under development, obesity, hypertension, cva and hyperlipidemia
1) Confidence 0.47 Published 2009 Journal Actas Urol Esp Section Abstract Doc Link 19900389 Disease Relevance 1.18 Pain Relevance 0.13
This modified trimeric SP-D variant would subsequently initiate a pro-inflammatory response via calreticulin/CD91 receptor interaction and activate p38 MAPK [48].
CD91 Binding (interaction) of associated with inflammatory response
2) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.94 Pain Relevance 0.37
LRP has been criticized for its difficult learning curve and its long operating times, allowing only limited centers of excellence to perform this technically demanding operation.
LRP Binding (criticized) of
3) Confidence 0.18 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.47 Pain Relevance 0
The different rates of uptake of CRLPs oxCRLPs and pCRLPs by macrophages demonstrated here, therefore, could be explained by effects on interaction with the LDLr and the LRP caused by differences both in the conformation of apoE and in the number of apoE molecules able to bind to the receptors, even though the total amount of apoE associated with the particles is not changed.
LRP Binding (interaction) of in macrophages
4) Confidence 0.10 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC1906864 Disease Relevance 0 Pain Relevance 0
The amino-termini of LRP and FZD were reported to associate only in the presence of Wnt [12], implying that Wnt ligands form a trimeric complex with an LRP and FZD receptor.
LRP Binding (associate) of
5) Confidence 0.06 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0.03

General Comments

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