INT1642

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Context Info
Confidence 0.58
First Reported 1973
Last Reported 2010
Negated 1
Speculated 6
Reported most in Abstract
Documents 40
Total Number 46
Disease Relevance 10.67
Pain Relevance 17.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
brain 4
hypothalamus 4
pituitary 4
gonadotroph 4
ventricles 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 147 100.00 Very High Very High Very High
Opioid 29 100.00 Very High Very High Very High
Dopamine 11 100.00 Very High Very High Very High
Delta opioid receptors 2 99.90 Very High Very High Very High
opiate 39 99.64 Very High Very High Very High
Endogenous opioid 46 99.54 Very High Very High Very High
antagonist 136 99.36 Very High Very High Very High
Inflammation 18 99.22 Very High Very High Very High
agonist 112 99.00 Very High Very High Very High
Pain threshold 2 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adenoma 10 99.90 Very High Very High Very High
Polycystic Ovary Syndrome 28 99.84 Very High Very High Very High
Stress 120 99.82 Very High Very High Very High
Hypoglycemia 18 99.82 Very High Very High Very High
Opiate Addiction 1 99.50 Very High Very High Very High
INFLAMMATION 18 99.22 Very High Very High Very High
Hyperphagia 3 99.22 Very High Very High Very High
Reprotox - General 1 58 99.08 Very High Very High Very High
Pain 40 98.70 Very High Very High Very High
Adverse Drug Reaction 1 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate the role of endogenous opioid pathways in the acute suppression of LH secretion by testosterone (T) infusion in men, we studied eight normal healthy volunteers who received a saline infusion, followed 1 week later by a T infusion (960 nmol/h) starting at 1000 h and lasting for 33 h.
Negative_regulation (suppression) of Localization (secretion) of LH associated with endogenous opioid
1) Confidence 0.58 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1430081 Disease Relevance 0 Pain Relevance 0.17
Morphine (13 mg/kg) and naloxone (1.3 mg/kg) were administered together to three fetuses (gestational age 94-105 days); LH secretion was sharply reduced from 411 +/- 14.3 ng/h ml-1 after naloxone alone to 53 +/- 17.5 ng/h ml-1 after the administration of both naloxone and morphine (P less than 0.01).
Negative_regulation (reduced) of Localization (secretion) of LH associated with narcan and morphine
2) Confidence 0.58 Published 1985 Journal Endocrinology Section Abstract Doc Link 3987627 Disease Relevance 0 Pain Relevance 0.83
This study was designed to evaluate whether the tonic inhibitory effect on LH secretion induced by opiates involves the serotoninergic system.
Spec (whether) Negative_regulation (effect) of Localization (secretion) of LH associated with opiate
3) Confidence 0.58 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3621624 Disease Relevance 0 Pain Relevance 0.66
Evidence that estrogens inhibit LH secretion through opioids in postmenopausal women using naloxone.
Negative_regulation (inhibit) of Localization (secretion) of LH associated with narcan and opioid
4) Confidence 0.58 Published 1984 Journal Neuroendocrinology Section Title Doc Link 6087184 Disease Relevance 0.09 Pain Relevance 0.51
Opioid peptides inhibit LH secretion and the opiate antagonist naloxone provokes increases in plasma LH levels by release of endogenous GnRH from the hypothalamus.
Negative_regulation (inhibit) of Localization (secretion) of LH in hypothalamus associated with antagonist, narcan, opiate and opioid
5) Confidence 0.57 Published 1985 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3914504 Disease Relevance 0 Pain Relevance 0.41
In the present study, we have examined in rhesus monkeys whether suppression of LH secretion by insulin-induced hypoglycemia is prevented by administration of the opiate antagonist naloxone.
Spec (whether) Negative_regulation (suppression) of Localization (secretion) of LH associated with hypoglycemia, antagonist, narcan and opiate
6) Confidence 0.55 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8388404 Disease Relevance 0.41 Pain Relevance 0.53
These data indicate that hypoglycemia-induced inhibition of LH secretion in chair-restrained ovariectomized monkeys is not mediated by endogenous opiates, since naloxone failed to reverse this effect.
Negative_regulation (inhibition) of Localization (secretion) of LH associated with hypoglycemia, narcan and opiate
7) Confidence 0.55 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8388404 Disease Relevance 0.56 Pain Relevance 0.48
A role for endogenous opioid peptides in stress-induced inhibition of LH secretion has been suggested based on the observation in rats, humans, and nonhuman primates that LH inhibition in response to a variety of different stresses could be blocked by the administration of opiate antagonists.
Negative_regulation (inhibition) of Localization (secretion) of LH associated with stress, antagonist, endogenous opioid and opiate
8) Confidence 0.55 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8388404 Disease Relevance 0.34 Pain Relevance 0.45
These findings suggest that in man, as in animals, gonadal hormones regulate opioid inhibition of LH secretion.
Negative_regulation (inhibition) of Localization (secretion) of LH in gonadal associated with opioid
9) Confidence 0.52 Published 1985 Journal Psychoneuroendocrinology Section Abstract Doc Link 3933025 Disease Relevance 0.15 Pain Relevance 0.52
It is well known that endogenous opioid peptides exert a tonic inhibitory control on GnRH release, leading to the inhibition of LH secretion, whereas eicosanoids, particularly prostaglandin E2(PGE2), stimulate GnRH output.
Negative_regulation (inhibition) of Localization (secretion) of LH associated with endogenous opioid
10) Confidence 0.51 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8626832 Disease Relevance 0 Pain Relevance 0.42
These data indicate that activation of delta-opioid receptors can reduce naloxone-induced LH release, suggesting a possible role of delta receptors in opioidergic modulation of LH secretion in women.
Negative_regulation (reduce) of Localization (release) of LH associated with narcan and delta opioid receptors
11) Confidence 0.47 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9647539 Disease Relevance 0 Pain Relevance 0.51
The authors carried out three sequential studies which demonstrated that heroin use in man results in acute suppression of luteinizing hormone (LH) release from the pituitary followed by a secondary drop in plasma testosterone levels.
Negative_regulation (suppression) of Localization (release) of LH in plasma associated with opiate addiction
12) Confidence 0.47 Published 1980 Journal Am J Psychiatry Section Abstract Doc Link 6774622 Disease Relevance 0.19 Pain Relevance 0.34
Whether the suppression of LH secretion after acute exercise in unconditioned males is due to factor(s) cosecreted with beta-LPH, an increase in brain beta-EP or to alternate mechanisms such as alteration in central dopaminergic or GABAergic tone remains to be established.
Spec (Whether) Negative_regulation (suppression) of Localization (secretion) of LH in brain associated with gabaergic
13) Confidence 0.47 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 2948941 Disease Relevance 0 Pain Relevance 0.19
Moreover, in these subjects naloxone reduced the inhibitory effects induced by DAMME but did not change the inhibitory effect of dopamine on LH secretion.
Negative_regulation (effect) of Localization (secretion) of LH associated with dopamine and narcan
14) Confidence 0.43 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.50
In addition, the administration of adrenergic inhibitors did not impede the capacity of naltrexone to significantly augment pulsatile LH secretion in these subjects.
Neg (not) Negative_regulation (impede) of Localization (secretion) of LH
15) Confidence 0.43 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313736 Disease Relevance 0 Pain Relevance 0.36
Moreover, the effectiveness of naloxone in augmenting LH release decreases with advancing gestational age.
Negative_regulation (decreases) of Localization (release) of LH associated with narcan
16) Confidence 0.43 Published 1985 Journal Endocrinology Section Abstract Doc Link 3987627 Disease Relevance 0 Pain Relevance 0.77
The negative feedback effects of T on LH secretion are primarily hypothalamic in early pubertal boys and change to pituitary suppression in men.
Negative_regulation (effects) of Localization (secretion) of LH in pituitary
17) Confidence 0.43 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1430081 Disease Relevance 0 Pain Relevance 0.29
Infusion of corticotropin-releasing hormone into the cerebral ventricles leads to inhibition of LH secretion in primates [11].
Negative_regulation (inhibition) of Localization (secretion) of LH in ventricles
18) Confidence 0.42 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416440 Disease Relevance 1.58 Pain Relevance 0.34
Evidence for decreased endogenous dopamine and opioid inhibitory influences on LH secretion in polycystic ovary syndrome.
Negative_regulation (decreased) of Localization (secretion) of LH in ovary associated with dopamine, narcan, polycystic ovary syndrome and opioid
19) Confidence 0.41 Published 1984 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 6088126 Disease Relevance 0.37 Pain Relevance 0.74
Injection of the mu-agonist at doses of 1 and 10 nmol produced a significant suppression of LH secretion, while the delta- and kappa-agonists had no significant effect.
Negative_regulation (suppression) of Localization (secretion) of LH associated with agonist
20) Confidence 0.39 Published 1983 Journal Peptides Section Abstract Doc Link 6318200 Disease Relevance 0 Pain Relevance 0.86

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