INT164205

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 12.31
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Proc) extracellular space (Proc) extracellular region (Proc)
Anatomy Link Frequency
B cell 1
tail 1
nucleus 1
Proc (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 165 96.40 Very High Very High Very High
Inflammation 121 94.32 High High
cytokine 71 81.80 Quite High
Arthritis 128 79.28 Quite High
Nerve growth factor 3 61.16 Quite High
Angina 1 52.96 Quite High
member 8 1 50.00 Quite Low
Pain 8 45.88 Quite Low
cINOD 13 23.60 Low Low
Kinase C 54 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 118 99.96 Very High Very High Very High
Disease 365 99.76 Very High Very High Very High
Hypertension 33 99.60 Very High Very High Very High
Vascular Dementia 51 99.48 Very High Very High Very High
Infection 6 98.94 Very High Very High Very High
Cardiovascular Disease 57 98.28 Very High Very High Very High
Hyperinsulinism 12 98.28 Very High Very High Very High
Hyperlipidemia 18 97.52 Very High Very High Very High
Ulcers 33 97.12 Very High Very High Very High
Diabetes Mellitus 152 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies about changes in protein intensities were complemented by an analysis of protein phosphorylation that revealed infection-associated changes in the phosphorylation of myosin binding protein C, atrial and ventricular isoforms of myosin regulatory light chain 2, desmin, and Rab GDP dissociation inhibitor beta-2.
protein C Binding (binding) of associated with infection
1) Confidence 0.36 Published 2010 Journal Proteomics Section Abstract Doc Link 20213679 Disease Relevance 0.98 Pain Relevance 0.05
R-SMADs interact with SMAD-4, the only known common mediator SMAD (CoSMAD) in mammals, and form heteromeric complexes which translocate to the nucleus where they influence gene expression (by binding to the DNA and acting as transcription factors, coactivators, and corepressors) [14–17].
factors Binding (binding) of in nucleus
2) Confidence 0.01 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0 Pain Relevance 0
METHODS: We conducted a chromatin immunoprecipitation (ChIP) screen to identify genes that bind the CDX transcription factors.
factors Binding (bind) of
3) Confidence 0.01 Published 2010 Journal Gastroenterology Section Body Doc Link 19900445 Disease Relevance 0 Pain Relevance 0
The increased production of mucus, in turn, also enhances the binding of growth factors with their receptors [36] and contributes to healing.
factors Binding (binding) of
4) Confidence 0.01 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.30 Pain Relevance 0
signaling pathways are important in bone metastases, interactions between these factors have not been reported.
factors Binding (interactions) of associated with metastasis
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.49 Pain Relevance 0
There are strong additional interactions with other risk factors, such as hypertension, hyperglycaemia and hyperinsulinaemia, hypercholesterolaemia, hyperlipidaemia, endothelial dysfunction, AGE formation and the ApoE4 genotype.
factors Binding (interactions) of associated with hypertension, hyperinsulinism and hyperlipidemia
6) Confidence 0.00 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.51 Pain Relevance 0
The strong association of cardiovascular risk factors with AD and VD suggests that these diseases share some biologic pathways.
factors Binding (association) of associated with vascular dementia and disease
7) Confidence 0.00 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 2.97 Pain Relevance 0.03
This correlation may be due to a strong association of cardiovascular risk factors with AD and VD, suggesting that these diseases share some biologic pathways.
factors Binding (association) of associated with vascular dementia and disease
8) Confidence 0.00 Published 2010 Journal The Open Biochemistry Journal Section Abstract Doc Link PMC2864432 Disease Relevance 2.40 Pain Relevance 0
IL-17RA has a long cytoplasmic tail, but factors that engage this tail are unknown, with the exception of TRAF6, which is needed for IL-17 signalling [137].
factors Binding (engage) of in tail
9) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.26 Pain Relevance 0.21
Although some autoantibodies, such as rheumatoid factors that recognize IgG and antibodies against citrullinated antigens, have diagnostic significance [8,29,30], the autoantigen(s) that are recognized in chronic inflammatory arthritides such as RA are unknown [5,16,22,31,32].
factors Binding (recognize) of associated with inflammation, rheumatoid arthritis and arthritis
10) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.41 Pain Relevance 0.57
These studies have provided important information about gene regulation in response to growth factors, regulation of immediate early genes, and the function and interaction of transcription factors.
factors Binding (interaction) of
11) Confidence 0.00 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 0.23 Pain Relevance 0.03
These findings have contributed to the rationale for the development of targeted therapies that delete B cells [60] or that attenuate the function of secreted and membrane associated factors that contribute to B cell accumulation and survival at sites of disease [61].
factors Binding (associated) of in B cell associated with disease
12) Confidence 0.00 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC2833442 Disease Relevance 0.77 Pain Relevance 0.30

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