INT164210

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.22
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cdx2) nucleus (Cdx2) DNA binding (Cdx2)
protein complex (Cdx2)
Anatomy Link Frequency
urinary bladder 1
embryos 1
colon 1
Cdx2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 1 100.00 Very High Very High Very High
Inflammation 1 92.56 High High
cytokine 2 92.04 High High
Pain 1 55.48 Quite High
Dysuria 1 54.28 Quite High
member 8 1 50.00 Quite Low
cINOD 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 24 99.52 Very High Very High Very High
INFLAMMATION 2 92.56 High High
Cancer 22 91.44 High High
Mucinous Adenocarcinoma 6 83.92 Quite High
Malignant Neoplastic Disease 3 76.28 Quite High
Metaplasia 6 73.92 Quite High
Clear Cell Adenocarcinoma 1 72.88 Quite High
Pain 1 55.48 Quite High
Overactive Bladder 1 54.68 Quite High
Premature Birth 1 54.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of Cdx1 or Cdx2 in human colon cancer cell lines induced expression of endogenous SLC5A8, whereas CDX1 and CDX2 knockdowns reduced its level.
Gene_expression (Overexpression) of Cdx2 in colon
1) Confidence 0.56 Published 2010 Journal Gastroenterology Section Body Doc Link 19900445 Disease Relevance 0 Pain Relevance 0
The results indicated that embryos that successfully generated pregnancies and successful fetuses displayed up-regulated expression of genes necessary for implantation (COX2, CDX2), carbohydrate metabolism (ALOX15), growth factor (BMP15), signal transduction (PLAU) and placental development (PLAC8), while embryos that failed to generate a pregnancy overexpressed inflammatory cytokines (TNF), protein amino acid binding (EEF1A1), transcription factors (MSX1, PTTG1) and glucose metabolism genes (El-Sayed et al., 2006).
Gene_expression (expression) of CDX2 in embryos associated with inflammation, cox2 and cytokine
2) Confidence 0.34 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.15 Pain Relevance 0.14
Regarding immunohistochemistry, adenocarcinoma of the urinary bladder expresses CEA, CDX-2, MUC-1, MUC-2 and MUC-3, same as colonic adenocarcinoma.
Gene_expression (expresses) of CDX-2 in urinary bladder associated with adenocarcinoma
3) Confidence 0.03 Published 2010 Journal Cases J Section Body Doc Link PMC2824640 Disease Relevance 2.07 Pain Relevance 0.11

General Comments

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