INT164229

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.08
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (LECT1) extracellular region (LECT1)
Anatomy Link Frequency
chondrocytes 3
cartilage 2
osteoblasts 1
TMJ 1
LECT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 36 100.00 Very High Very High Very High
Mechanotransduction 2 96.80 Very High Very High Very High
Osteoarthritis 80 72.28 Quite High
imagery 11 7.64 Low Low
metalloproteinase 34 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 36 100.00 Very High Very High Very High
Osteoarthritis 84 85.20 High High
Choroideremia 166 81.12 Quite High
Pallor 1 78.64 Quite High
Frailty 2 74.28 Quite High
Death 3 74.16 Quite High
Myopia 1 63.20 Quite High
Disease 28 31.96 Quite Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ChM-1 and VEGF were both similarly expressed in perforated disc tissues.
Gene_expression (expressed) of ChM-1
1) Confidence 0.67 Published 2010 Journal J. Oral Pathol. Med. Section Body Doc Link 19903245 Disease Relevance 0.14 Pain Relevance 0
In TMJ, ChM-1 was expressed in the proliferative and hypertrophic zone of condylar cartilage and chondrocyte-like cells in the disc.
Gene_expression (expressed) of ChM-1 in chondrocyte
2) Confidence 0.67 Published 2010 Journal J. Oral Pathol. Med. Section Body Doc Link 19903245 Disease Relevance 0.15 Pain Relevance 0
No expression of ChM-1 was observed in osteoblasts and subchondral bone.
Gene_expression (expression) of ChM-1 in osteoblasts
3) Confidence 0.67 Published 2010 Journal J. Oral Pathol. Med. Section Body Doc Link 19903245 Disease Relevance 0.14 Pain Relevance 0
ChM-1 expression in TMJ condylar cartilage and disc was determined by immunohistochemistry.
Gene_expression (expression) of ChM-1 in cartilage
4) Confidence 0.67 Published 2010 Journal J. Oral Pathol. Med. Section Body Doc Link 19903245 Disease Relevance 0.18 Pain Relevance 0
In this study, we investigated the expression of the anti-angiogenic factor, chondromodulin-1 (ChM-1), in TMJ cartilage and evaluate its potential role in TMJ remodeling.
Spec (investigated) Gene_expression (expression) of ChM-1 in TMJ associated with snapping jaw
5) Confidence 0.67 Published 2010 Journal J. Oral Pathol. Med. Section Abstract Doc Link 19903245 Disease Relevance 0.54 Pain Relevance 0.54
In addition, surviving chondrocytes undergo a phenotypic shift that includes expression of inappropriate matrix molecules[20-22], decreased sensitivity to insulin like growth factor-1 (IGF-1)[23], increased expression of vascular endothelial growth factor (VEGF) and VEGF receptor[24,25], decreased expression of chondromodulin-I (ChM-I)[24], altered interleukin (IL)-4 signaling[25], and altered integrin-dependent mechanotransduction pathways[26].
Gene_expression (expression) of chondromodulin-I in chondrocytes associated with mechanotransduction
6) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1636033 Disease Relevance 0.48 Pain Relevance 0.21
In addition, surviving chondrocytes undergo a phenotypic shift that includes expression of inappropriate matrix molecules[20-22], decreased sensitivity to insulin like growth factor-1 (IGF-1)[23], increased expression of vascular endothelial growth factor (VEGF) and VEGF receptor[24,25], decreased expression of chondromodulin-I (ChM-I)[24], altered interleukin (IL)-4 signaling[25], and altered integrin-dependent mechanotransduction pathways[26].
Gene_expression (expression) of ChM-I in chondrocytes associated with mechanotransduction
7) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1636033 Disease Relevance 0.48 Pain Relevance 0.21
At age 29, the ERG of another patient (CHM1) showed severe reduction in the amplitudes of the scotopic b wave and photopic responses only 10% of normal.
Gene_expression (reduction) of CHM1
8) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.80 Pain Relevance 0
In TMJ, ChM-1 was expressed in the proliferative and hypertrophic zone of condylar cartilage and chondrocyte-like cells in the disc.
Gene_expression (expressed) of ChM-1 in cartilage
9) Confidence 0.23 Published 2010 Journal J. Oral Pathol. Med. Section Body Doc Link 19903245 Disease Relevance 0.15 Pain Relevance 0

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