INT164248

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 24.54
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MPZ) plasma membrane (MPZ)
Anatomy Link Frequency
Tooth 2
lobe 1
lung 1
blood cells 1
MPZ (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 479 100.00 Very High Very High Very High
Pain 46 99.28 Very High Very High Very High
headache 9 96.48 Very High Very High Very High
Peripheral nervous system 10 82.36 Quite High
agonist 10 81.60 Quite High
cva 10 80.24 Quite High
imagery 3 70.96 Quite High
Pain score 4 69.12 Quite High
Inflammatory mediators 22 66.08 Quite High
cytokine 78 64.80 Quite High
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 1401 100.00 Very High Very High Very High
Dengue 609 100.00 Very High Very High Very High
INFLAMMATION 535 100.00 Very High Very High Very High
Syndrome 122 100.00 Very High Very High Very High
Neuropathic Pain 62 100.00 Very High Very High Very High
Mouth Disease 37 100.00 Very High Very High Very High
Infection 281 99.90 Very High Very High Very High
Occupational Lung Diseases 48 99.50 Very High Very High Very High
Targeted Disruption 9 99.38 Very High Very High Very High
Pain 47 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Epidemiological evidence in Hawaii, Cuba, and Thailand[9] shows populations with previous exposure to the dengue virus are at an increased risk for DHF/DSS.
Positive_regulation (increased) of DSS associated with dengue and dengue hemorrhagic fever
1) Confidence 0.67 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 1.23 Pain Relevance 0.09
The increase in the MPP of 4 feet after MP placement is also noteworthy; of these, 3 rated the symptoms as worse, while one rated as no improvement during the follow-up.
Positive_regulation (increase) of MPP
2) Confidence 0.58 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.24 Pain Relevance 0.17
The Val102fs mutation of the myelin protein zero gene (MPZ) has been associated with Charcot-Marie-Tooth disease type 1B (CMT1B).
Positive_regulation (mutation) of MPZ in Tooth associated with charcot marie tooth disease and mouth disease
3) Confidence 0.49 Published 2009 Journal Neuromuscul. Disord. Section Abstract Doc Link 19906531 Disease Relevance 1.02 Pain Relevance 0.11
However, we still found 4 feet in which the MPP was elevated after MP placement (Figure 1).
Positive_regulation (elevated) of MPP
4) Confidence 0.39 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.34 Pain Relevance 0
First, we identify a transcriptional signature of the DSS, differentiating DSS from the other forms of dengue infection and characterizing DSS as a unique and specific entity.
Positive_regulation (differentiating) of DSS associated with dengue, dengue hemorrhagic fever and infection
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 2.79 Pain Relevance 0.04
First, we identify a transcriptional signature of the DSS, differentiating DSS from the other forms of dengue infection and characterizing DSS as a unique and specific entity.
Positive_regulation (characterizing) of DSS associated with dengue, dengue hemorrhagic fever and infection
6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 2.81 Pain Relevance 0.04
When searching for pro-inflammatory gene patterns that may be relevant to DSS pathophysiology and particularly to systemic inflammation and vascular dysfunction, we identified three major pro-inflammatory gene patterns.
Positive_regulation (relevant) of DSS associated with inflammation and dengue hemorrhagic fever
7) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.40 Pain Relevance 0.46
Activation of a pro-inflammatory defence gene pattern in DSS patients' blood cells (Table 4) has relevance to the pathophysiology of systemic vascular dysfunction, since most microbicidal peptides and enzymes have recognized pro-inflammatory and pathogenic effects towards vascular endothelial tissues [50].
Positive_regulation (Activation) of DSS in blood cells associated with inflammation and dengue hemorrhagic fever
8) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.62 Pain Relevance 0.40
Pro-inflammatory innate defense and host-lipid metabolism-related transcriptional responses are activated in DSS children
Positive_regulation (activated) of DSS associated with inflammation and dengue hemorrhagic fever
9) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.41 Pain Relevance 0.48
Clinically missense mutations in the MPZ gene can cause congenital hypomyelinating neuropathy (CH), DSS, CMT type 1, CMT type 2 and intermediate CMT [6,16-22].
Positive_regulation (cause) of CMT type 1 associated with syndrome and neuropathic pain
10) Confidence 0.15 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 0.98 Pain Relevance 0
Asp35Tyr causes intermediate CMT, CMT type 1 and CMT type 2 [16,17].
Positive_regulation (intermediate) of CMT type 1
11) Confidence 0.14 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 0.41 Pain Relevance 0
Asp35Tyr causes intermediate CMT, CMT type 1 and CMT type 2 [16,17].
Positive_regulation (causes) of CMT type 1
12) Confidence 0.14 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 0.41 Pain Relevance 0
The Ser63del causes a demyelinating neuropathy in transgenic mice, similar to the Ser63del causes a CMT type 1 in humans [24-26].
Positive_regulation (causes) of CMT type 1 associated with targeted disruption, neuropathic pain and demyelinating disease
13) Confidence 0.13 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 0.87 Pain Relevance 0.06
Understanding why protein biosynthesis may be increased in DSS patients requires further studies.
Positive_regulation (increased) of DSS associated with dengue hemorrhagic fever
14) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.49 Pain Relevance 0
In HLA class I, frequency of the HLA-A*24 showed increased tendency in both DHF and DSS patients, which reproduced a previous study.
Positive_regulation (increased) of DSS associated with dengue hemorrhagic fever
15) Confidence 0.04 Published 2008 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2553281 Disease Relevance 2.10 Pain Relevance 0
Infection by any of the 4 serotypes of DV, DEN-1, -2, -3, and -4, may result in no symptoms, dengue fever (DF, without any serious complications), DHF or DSS.
Neg (no) Spec (may) Positive_regulation (result) of DSS associated with dengue, dengue hemorrhagic fever and infection
16) Confidence 0.04 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 3.22 Pain Relevance 0.20
There are almost two dozen known genes that can mutate to cause CMT, and these fall into a wide variety of biochemical cellular pathways.
Positive_regulation (cause) of CMT in CMT associated with mouth disease
17) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2928813 Disease Relevance 1.23 Pain Relevance 0.04
Invasive studies have been carried out in patients with asymptomatic asthma using a catheter-tipped micromanometer wedged into the lower lobe of the bronchus in order to partition central and peripheral airway resistance.[6] In those studies, the investigators constructed separate dose-response curves in vivo and showed a dose-dependent increase in both central and peripheral airway resistance in response to inhaled MCh in all patients studied.
Positive_regulation (increase) of peripheral in lobe associated with asthma
18) Confidence 0.01 Published 2007 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2732069 Disease Relevance 0.16 Pain Relevance 0
More recently peripheral airways, including lung tissue, have been recognized as a predominant site of airflow obstruction in asthmatics.[5853] In partitioning the central and peripheral airway resistance in awake humans, Yanai and colleagues have demonstrated a dramatically increased contribution of the distal airways to the total lung resistance in patients with moderate-to-severe asthma when compared to normals or to patients with mild asthma.[5] In these patients, lung function measurements were performed in a single lobe of the lung and it may be argued this is not an accurate depiction of total lung resistance; however, these values were similar to those measured throughout postmortem human lung specimens.[54] Furthermore, Wagner and colleagues have shown that in mild asthmatics with normal spirometry, the distal airway resistance was increased up to sevenfold when compared to controls and these measurements correlated with responsiveness to MCh.[55] In addition, asymptomatic asthmatics can exhibit significant increases in peripheral airway resistance, which is likely to be a result of distal lung inflammation.
Positive_regulation (increases) of peripheral in lung associated with asthma, inflammation, pneumonia and occupational lung diseases
19) Confidence 0.01 Published 2007 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2732069 Disease Relevance 0.81 Pain Relevance 0.08

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