INT164251

Context Info Confidence 0.34 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.22

extracellular space (Ghrl, Gnrh1) extracellular region (Ghrl, Gnrh1) molecular_function (Gnrh1) cytoplasm (Ghrl)

Ghrl (Rattus norvegicus) Gnrh1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat narcan 4 99.74 Opioid 2 86.28 antagonist 2 86.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Hypothalamic Ghrelin suppresses pulsatile secretion of luteinizing hormone via beta-endorphin in ovariectomized rats.

Ghrelin Negative_regulation (suppresses) of Localization (secretion) of luteinizing hormone associated with narcan

1) Confidence 0.34 Published 2009 Journal Neuroendocrinology Section Title Doc Link 19907132 Disease Relevance 0 Pain Relevance 0.22

CONCLUSION: Suppressive effect of intracerebroventricular injection of ghrelin on pulsatile LH secretion was mediated by beta-END, suggesting that hypothalamic ghrelin suppressed pulsatile gonadotropin-releasing hormone secretion via beta-END in female rats.

ghrelin Negative_regulation (suppressed) of Localization (secretion) of gonadotropin-releasing hormone

2) Confidence 0.30 Published 2009 Journal Neuroendocrinology Section Body Doc Link 19907132 Disease Relevance 0 Pain Relevance 0

General Comments

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