INT164260

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 4.29
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
animal tissue 4
H19 (Homo sapiens)
Pain Link Frequency Relevance Heat
Duloxetine 1 100.00 Very High Very High Very High
dexamethasone 1 98.08 Very High Very High Very High
Adalimumab 1 90.30 High High
Gabapentin 1 88.84 High High
Morphine 1 69.44 Quite High
anesthesia 5 62.44 Quite High
pregabalin 1 60.60 Quite High
ketamine 5 39.96 Quite Low
Ziconotide 1 37.00 Quite Low
palliative 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 20 99.84 Very High Very High Very High
Starvation 10 99.00 Very High Very High Very High
Cancer 345 98.72 Very High Very High Very High
Pancreatic Cancer 160 95.28 Very High Very High Very High
Adenocarcinoma 15 94.88 High High
Papillomavirus Infection 1 87.56 High High
Metastasis 85 75.04 Quite High
Pancreatic Ductal Carcinoma 10 72.56 Quite High
Diphtheria 20 23.64 Low Low
Disease 15 7.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies showed that H19 gene expression may be induced by hypoxia and/or serum starvation conditions and that the H19 gene may play a role in tumorogenesis [17, 20].
Positive_regulation (induced) of Gene_expression (expression) of H19 associated with starvation and hypoxia
1) Confidence 0.67 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.62 Pain Relevance 0
Results showed that 65% of the tested samples were positive for H19 expression (Figures 1(a) and 1(b)).

3.2.

Positive_regulation (positive) of Gene_expression (expression) of H19
2) Confidence 0.45 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.88 Pain Relevance 0.06
The different cell lines used in this investigation were chosen because of their differences in the level of H19 gene expression and their response to transfection procedure.
Positive_regulation (level) of Gene_expression (expression) of H19
3) Confidence 0.45 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.26 Pain Relevance 0
High levels of H19 gene expression were detected in the developed tumors even though no expression was detected in cultured cells (Figure 5), which is in agreement with previous observations establishing that H19 gene expression may be induced by hypoxia and/or serum starvation conditions developed following injection of tumor cells into the animal tissue [17].
Positive_regulation (induced) of Gene_expression (expression) of H19 in animal tissue associated with starvation, hypoxia and cancer
4) Confidence 0.45 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.20 Pain Relevance 0
High levels of H19 gene expression were detected in the developed tumors even though no expression was detected in cultured cells (Figure 5), which is in agreement with previous observations establishing that H19 gene expression may be induced by hypoxia and/or serum starvation conditions developed following injection of tumor cells into the animal tissue [17].
Positive_regulation (levels) of Gene_expression (expression) of H19 in animal tissue associated with starvation, hypoxia and cancer
5) Confidence 0.45 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.25 Pain Relevance 0
This issue focuses on the following selection of drugs: AAV1/SERCA2a, Abacavir sulfate/lamivudine, Adalimumab, Aliskiren fumarate, Ambrisentan, Aripiprazole, AT-7519, Atazanavir sulfate, Atomoxetine hydrochloride, Azacitidine, Azelnidipine; Besifloxacin hydrochloride, Bevacizumab, Bioabsorbable everolimus-eluting coronary stent, Bortezomib, Bosentan, Budesonide/formoterol fumarate; CAIV-T, Carisbamate, Casopitant mesylate, Certolizumab pegol, Cetuximab, Ciclesonide, Ciprofloxacin/dexamethasone, CTCE-9908; Dalcetrapib, Darunavir, Deferasirox, Desloratadine, Disitertide, Drotrecogin alfa (activated), DTA-H19, Duloxetine hydrochloride, Dutasteride; Ecogramostim, Efalizumab, Emtricitabine, Eribulin mesilate, Escitalopram oxalate, Eszopiclone, EUR-1008, Everolimus-eluting coronary stent, Exenatide; Fampridine, Fluticasone furoate, Formoterol fumarate/fluticasone propionate, Fosamprenavir calcium, Fulvestrant; Gabapentin enacarbil, GS-7904L; HPV-6/11/16/18, Human Secretin, Hydralazine hydrochloride/isosorbide dinitrate; Imatinib mesylate, Imexon, Inalimarev/Falimarev, Indacaterol, Indacaterol maleate, Inhalable human insulin, Insulin detemir, Insulin glargine, Ixabepilone; L-Alanosine, Lapatinib ditosylate, Lenalidomide, Levocetirizine dihydrochloride, Liraglutide, Lisdexamfetamine mesilate, Lopinavir, Loratadine/montelukast sodium, Lutropin alfa; MeNZB, Mepolizumab, Micafungin sodium, Morphine hydrochloride; Nabiximols, Nikkomycin Z; Olmesartan medoxomil, Omalizumab; Paclitaxel-eluting stent, Pegfilgrastim, Peginterferon alfa-2a, Peginterferon alfa-2b, Perifosine, PF-489791, Plitidepsin, Posaconazole, Pregabalin; QAX-576; Raltegravir potassium, Ramelteon, Rasagiline mesilate, Recombinant human relaxin H2, rhGAD65, Rivaroxaban, Rosuvastatin calcium, Rotigotine; Saxagliptin, SCH-530348, Sirolimus-eluting stent, SLIT-amikacin, Sorafenib, Sotrastaurin, SR-16234, Sulforaphane; Tadalafil, Tanespimycin, Tapentadol hydrochloride, Teriparatide, Tesofensine, Tiotropium bromide, Tipifarnib, Tirapazamine, TMC-207, Tocilizumab, Tolvaptan, Tosedostat, Treprostinil sodium; Ustekinumab; Varespladib methyl, Vicriviroc, Vildagliptin, Vildagliptin/metformin hydrochloride, Volociximab, Voriconazole; Ziconotide, Ziprasidone hydrochloride.
Positive_regulation (activated) of Gene_expression (hydrochloride) of DTA-H19 associated with pregabalin, papillomavirus infection, ziconotide, adalimumab, gabapentin, duloxetine, dexamethasone and morphine
6) Confidence 0.04 Published 2009 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 19907722 Disease Relevance 0.09 Pain Relevance 0.36

General Comments

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