INT164263

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.08 Pain Relevance 0.54

signal transduction (CCND3) nucleus (CCND3) transferase activity, transferring acyl groups (TGM7) cell division (CCND3) cytoplasm (CCND3)

TGM7 (Homo sapiens) CCND3 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 9 100.00 cINOD 2 76.40 Inflammation 1 72.80 agonist 1 60.00

Disease Link Frequency Relevance Heat Apoptosis 4 96.24 Lung Cancer 2 94.92 Cancer 2 82.32 Cardiovascular Disease 1 80.56 Colon Cancer 1 79.48 INFLAMMATION 2 75.84 Insulin Resistance 1 67.60 Diabetes Mellitus 1 65.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In Western blot, combined TGZ and ASA also could downregulate Cdk2, E2F-1, cyclin B1, cyclin D3 protein, and the ratio of phospho-Rb/Rb.

TGZ Negative_regulation (downregulate) of cyclin D3 protein associated with aspirin

1) Confidence 0.04 Published 2010 Journal Mol. Carcinog. Section Abstract Doc Link 19908241 Disease Relevance 1.08 Pain Relevance 0.54

General Comments

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