INT164272

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.34
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cysltr1) cellular_component (Cysltr1) signal transducer activity (Cysltr1)
Anatomy Link Frequency
nasal mucosa 2
nerve 1
microglia 1
Cysltr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 156 99.28 Very High Very High Very High
Spinal cord 8 99.12 Very High Very High Very High
dorsal root ganglion 30 98.76 Very High Very High Very High
Peripheral nerve injury 5 96.40 Very High Very High Very High
Potency 2 95.76 Very High Very High Very High
Neuropathic pain 7 95.04 Very High Very High Very High
Hyperalgesia 2 93.88 High High
antagonist 21 92.72 High High
Thermal hyperalgesia 10 91.44 High High
IPN 5 91.00 High High
Disease Link Frequency Relevance Heat
Chronic Sinusitis 2 98.96 Very High Very High Very High
Nervous System Injury 13 98.92 Very High Very High Very High
Ganglion Cysts 31 98.76 Very High Very High Very High
Asthma 116 98.40 Very High Very High Very High
Hypersensitivity 23 98.28 Very High Very High Very High
Neuropathic Pain 9 95.04 Very High Very High Very High
Hyperalgesia 12 93.88 High High
Inflammatory Pain 5 91.00 High High
Rheumatoid Arthritis 6 89.64 High High
Disease 2 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using double labeling analysis of in situ hybridization with immunohistochemistry, we observed that 5-LO, FLAP, and CysLT1 mRNAs were expressed in spinal microglia.
Gene_expression (expressed) of CysLT1 in microglia
1) Confidence 0.59 Published 2010 Journal Glia Section Abstract Doc Link 19908283 Disease Relevance 1.06 Pain Relevance 0.66
In the present study, we demonstrated the expression of LT receptors, BLT1, BLT2, CysLT1, and CysLT2, in the adult rat DRG.
Gene_expression (expression) of CysLT1 associated with dorsal root ganglion
2) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 1.21 Pain Relevance 1.12
Using the spared nerve injury (SNI) model in rats, we investigated the expression of LT synthases (5-lipoxygenase; 5-LO, Five lipoxygenase activating protein; FLAP, LTA4 hydrolase; LTA4h and LTC4 synthase; LTC4s) and receptors (BLT1, 2 and CysLT1, 2) mRNAs in the rat spinal cord.
Gene_expression (synthases) of CysLT1 in nerve associated with nervous system injury and spinal cord
3) Confidence 0.44 Published 2010 Journal Glia Section Abstract Doc Link 19908283 Disease Relevance 1.07 Pain Relevance 0.55
Sousa et al. reported that the number of cells expressing CYSLTR1 in the nasal mucosa is significantly higher in cases of AIA with chronic rhinosinusitis than in aspirin-tolerant patients, suggesting that CYSLTR1 overexpression is crucial to the pathogenesis of aspirin hypersensitivity.4 CysLTs bind to CYSLTR1 with a rank order of potency of LTD4>LTC4>LTE4,24 and the receptor is antagonized selectively by currently available leukotriene modifiers, including MLK, pranlukast, and zafirlukast.8,9
Gene_expression (expressing) of CYSLTR1 in nasal mucosa associated with asthma, aspirin, chronic sinusitis, hypersensitivity and potency
4) Confidence 0.23 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2831603 Disease Relevance 0.48 Pain Relevance 0.28
Sousa et al. reported that the number of cells expressing CYSLTR1 in the nasal mucosa is significantly higher in cases of AIA with chronic rhinosinusitis than in aspirin-tolerant patients, suggesting that CYSLTR1 overexpression is crucial to the pathogenesis of aspirin hypersensitivity.4 CysLTs bind to CYSLTR1 with a rank order of potency of LTD4>LTC4>LTE4,24 and the receptor is antagonized selectively by currently available leukotriene modifiers, including MLK, pranlukast, and zafirlukast.8,9
Gene_expression (overexpression) of CYSLTR1 in nasal mucosa associated with asthma, aspirin, chronic sinusitis, hypersensitivity and potency
5) Confidence 0.23 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2831603 Disease Relevance 0.51 Pain Relevance 0.29

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