INT164273

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Context Info
Confidence 0.74
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.95
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cysltr2) molecular_function (Cysltr2) cellular_component (Cysltr2)
signal transducer activity (Cysltr2)
Anatomy Link Frequency
neurons 2
neuronal 1
IB4 1
nociceptors 1
Cysltr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
unmyelinated 20 99.76 Very High Very High Very High
primary afferent fibers 5 99.40 Very High Very High Very High
nociceptor 15 98.86 Very High Very High Very High
dorsal root ganglion 150 98.76 Very High Very High Very High
Calcitonin gene-related peptide 45 97.62 Very High Very High Very High
Pain 40 96.72 Very High Very High Very High
Spinal cord 22 96.68 Very High Very High Very High
agonist 40 96.36 Very High Very High Very High
Thermal hyperalgesia 50 91.52 High High
Peripheral nerve injury 7 85.44 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 11 100.00 Very High Very High Very High
Ganglion Cysts 155 98.76 Very High Very High Very High
Pain 40 96.72 Very High Very High Very High
Hyperalgesia 60 91.52 High High
Neuropathic Pain 9 84.08 Quite High
Inflammatory Pain 16 80.04 Quite High
Rheumatoid Arthritis 21 78.68 Quite High
Pressure And Volume Under Development 10 78.00 Quite High
Asthma 11 77.80 Quite High
Disease 1 77.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leukotrienes are known as proinflammatory lipid mediators, and CysLT2 was co-localized with TRPV1, a heat sensor, in DRG neurons.
Localization (localized) of CysLT2 in neurons associated with dorsal root ganglion
1) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.42 Pain Relevance 0.59
Next, to examine whether CysLT2 mRNA was co-expressed with TRPV1 and P2X3 that are considered as pivotal nociceptors in primary afferent fibers, we tested the percentage of colocalization of CysLT2 mRNA with TRPV1 and P2X3.
Localization (colocalization) of CysLT2 mRNA in nociceptors associated with primary afferent fibers and nociceptor
2) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.06 Pain Relevance 0.51
Semi-quantitative RT-PCR revealed that 5-LO, FLAP, LTC4s, BLT1, and CysLT1 mRNAs increased following SNI, but not CysLT2 mRNAs.
Localization (increased) of CysLT2 associated with nervous system injury
3) Confidence 0.73 Published 2010 Journal Glia Section Abstract Doc Link 19908283 Disease Relevance 1.10 Pain Relevance 0.60
Interestingly, CysLT2 mRNA expressing neurons were heavily co-localized with TRPV1- or P2X3-positive neurons.
Localization (localized) of CysLT2 mRNA in neurons
4) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.54 Pain Relevance 0.43
The brightfield and high magnification images confirmed the presence of CysLT2 on neuronal cell bodies (Figure 1E).
Localization (presence) of CysLT2 in neuronal
5) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.74 Pain Relevance 0.35
Double labeling analysis of CysLT2 with NF-200, calcitonin gene-related peptide (CGRP), isolectin B4 (IB4), transient receptor potential vanilloid subfamily 1 (TRPV1) and P2X3 receptor revealed that many CysLT2-labeled neurons were localized with unmyelinated and non-peptidergic neurons, and interestingly, CysLT2 mRNA heavily co-localized with TRPV1 and P2X3-positive neurons.
Localization (localized) of CysLT2-labeled in IB4 associated with unmyelinated and calcitonin gene-related peptide
6) Confidence 0.57 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2949724 Disease Relevance 1.09 Pain Relevance 0.92

General Comments

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