INT164275

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.79
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5ap) nuclear envelope (Alox5ap) endoplasmic reticulum (Alox5ap)
nucleus (Alox5ap) enzyme binding (Alox5ap)
Anatomy Link Frequency
nerve 2
microglia 1
Alox5ap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 6 97.08 Very High Very High Very High
Spinal cord 6 96.44 Very High Very High Very High
Neuropathic pain 9 95.72 Very High Very High Very High
IPN 3 91.68 High High
rheumatoid arthritis 3 90.32 High High
Inflammation 12 88.44 High High
intrathecal 3 77.92 Quite High
antagonist 3 71.76 Quite High
allodynia 3 69.04 Quite High
corticosteroid 1 52.16 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 18 99.26 Very High Very High Very High
Chronic Sinusitis 44 98.48 Very High Very High Very High
Neuropathic Pain 12 95.72 Very High Very High Very High
Inflammatory Pain 3 91.68 High High
Rheumatoid Arthritis 3 90.32 High High
Asthma 14 89.44 High High
Disease 26 88.80 High High
INFLAMMATION 12 88.44 High High
Eosinophilia 6 68.48 Quite High
Nicotine Addiction 2 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using double labeling analysis of in situ hybridization with immunohistochemistry, we observed that 5-LO, FLAP, and CysLT1 mRNAs were expressed in spinal microglia.
Gene_expression (expressed) of FLAP in microglia
1) Confidence 0.55 Published 2010 Journal Glia Section Abstract Doc Link 19908283 Disease Relevance 1.06 Pain Relevance 0.66
Using the spared nerve injury (SNI) model in rats, we investigated the expression of LT synthases (5-lipoxygenase; 5-LO, Five lipoxygenase activating protein; FLAP, LTA4 hydrolase; LTA4h and LTC4 synthase; LTC4s) and receptors (BLT1, 2 and CysLT1, 2) mRNAs in the rat spinal cord.
Gene_expression (hydrolase) of FLAP in nerve associated with nervous system injury and spinal cord
2) Confidence 0.54 Published 2010 Journal Glia Section Abstract Doc Link 19908283 Disease Relevance 1.05 Pain Relevance 0.51
Using the spared nerve injury (SNI) model in rats, we investigated the expression of LT synthases (5-lipoxygenase; 5-LO, Five lipoxygenase activating protein; FLAP, LTA4 hydrolase; LTA4h and LTC4 synthase; LTC4s) and receptors (BLT1, 2 and CysLT1, 2) mRNAs in the rat spinal cord.
Spec (investigated) Gene_expression (expression) of Five lipoxygenase activating protein in nerve associated with nervous system injury and spinal cord
3) Confidence 0.49 Published 2010 Journal Glia Section Abstract Doc Link 19908283 Disease Relevance 1.07 Pain Relevance 0.52
These SNPs were found in the ALOX5 (rs3780894), ALOX5AP (rs17612127) and CYSTLR1 (rs321090) genes.
Gene_expression (found) of ALOX5AP
4) Confidence 0.13 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2292155 Disease Relevance 0.61 Pain Relevance 0.03

General Comments

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