INT164278

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.30
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cysltr1) cellular_component (Cysltr1) signal transducer activity (Cysltr1)
Cysltr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 2 97.20 Very High Very High Very High
aspirin 78 87.96 High High
Peripheral nerve injury 2 85.96 High High
Neuropathic pain 3 84.60 Quite High
IPN 1 80.56 Quite High
rheumatoid arthritis 1 79.20 Quite High
Inflammation 3 77.32 Quite High
cINOD 2 68.84 Quite High
intrathecal 1 63.44 Quite High
antagonist 10 60.04 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 99.56 Very High Very High Very High
Asthma 57 98.84 Very High Very High Very High
Occupational Lung Diseases 4 85.16 High High
Neuropathic Pain 4 84.60 Quite High
Inflammatory Pain 1 80.56 Quite High
Rheumatoid Arthritis 1 79.20 Quite High
Disease 1 77.68 Quite High
INFLAMMATION 4 77.32 Quite High
Hypersensitivity 11 72.20 Quite High
Bronchospasm 17 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Semi-quantitative RT-PCR revealed that 5-LO, FLAP, LTC4s, BLT1, and CysLT1 mRNAs increased following SNI, but not CysLT2 mRNAs.
Localization (increased) of CysLT1 associated with nervous system injury
1) Confidence 0.57 Published 2010 Journal Glia Section Abstract Doc Link 19908283 Disease Relevance 1.10 Pain Relevance 0.60
CysLTs exert their biological actions by binding to two types of G protein-coupled receptors, i.e., cysteinyl leukotriene receptor 1 (CYSLTR1), which is sensitive to the asthma drugs montelukast (MLK), zafirlukast, and pranlukast,8,9 and CYSLTR2.10
Localization (i.e.) of CYSLTR1 associated with asthma
2) Confidence 0.29 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2831603 Disease Relevance 1.21 Pain Relevance 0.41

General Comments

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