INT16428

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Context Info
Confidence 0.20
First Reported 1990
Last Reported 2011
Negated 3
Speculated 2
Reported most in Abstract
Documents 135
Total Number 139
Disease Relevance 106.44
Pain Relevance 26.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
macrophages 6
platelet 4
nerve 4
T cell 4
heart 3
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1426 100.00 Very High Very High Very High
cytokine 756 100.00 Very High Very High Very High
Nerve growth factor 34 100.00 Very High Very High Very High
cINOD 209 99.96 Very High Very High Very High
nociceptor 15 99.90 Very High Very High Very High
Dopamine 202 99.86 Very High Very High Very High
metalloproteinase 182 99.84 Very High Very High Very High
Paracetamol 43 99.84 Very High Very High Very High
Inflammatory stimuli 15 99.82 Very High Very High Very High
Peripheral nerve injury 14 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2133 100.00 Very High Very High Very High
INFLAMMATION 1630 100.00 Very High Very High Very High
Diabetes Mellitus 412 100.00 Very High Very High Very High
Obesity 330 100.00 Very High Very High Very High
Hypoxia 329 100.00 Very High Very High Very High
Necrosis 165 100.00 Very High Very High Very High
Pancreatitis 9 100.00 Very High Very High Very High
Alzheimer's Dementia 116 99.98 Very High Very High Very High
Hyperglycemia 20 99.98 Very High Very High Very High
Disease 1285 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We performed a crush injury of the sciatic nerve in old and senescence accelerated mice and found that the peripheral nerves of these animals are unable to locally upregulate vascular endothelial growth factor (VEGF), a prototypical angiogenic cytokine, after injury and have substantial deficits in mounting an appropriate intraneural angiogenic response during nerve regeneration.
Neg (unable) Positive_regulation (upregulate) of factor in sciatic nerve associated with aging, injury, sciatic nerve and cytokine
1) Confidence 0.20 Published 2004 Journal Neurobiol. Aging Section Abstract Doc Link 15465634 Disease Relevance 0.79 Pain Relevance 0.17
Elucidating the secondary signaling molecules that are necessary for platelet-derived growth factor (PDGF) to stimulate tumor development will be crucial to the understanding and treatment of a variety of cancers.
Positive_regulation (necessary) of factor in platelet associated with cancer
2) Confidence 0.16 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 11855867 Disease Relevance 0.19 Pain Relevance 0
We recently reported that APAP likewise inhibits serum growth factor activation of NF-kappaB in a mouse hepatoma cell line (Hepa 1-6 cells).
Positive_regulation (activation) of factor in Hepa 1-6 associated with paracetamol and hepatocellular cancer
3) Confidence 0.13 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10828269 Disease Relevance 0.19 Pain Relevance 0.73
We reported previously that vascular endothelial growth factor (VEGF) was increased in acetaminophen (APAP) toxicity in mice and treatment with a VEGF receptor inhibitor reduced hepatocyte regeneration.
Positive_regulation (increased) of factor in hepatocyte associated with toxicity and paracetamol
4) Confidence 0.11 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20363854 Disease Relevance 0.49 Pain Relevance 0.62
Bone marrow cells from mice implanted with morphine pellets for 72 h showed a 65% decrease in their response to macrophage colony stimulating factor (M-CSF).
Positive_regulation (response) of factor in macrophage associated with morphine
5) Confidence 0.11 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1831136 Disease Relevance 0 Pain Relevance 0.75
Neurons classified as nociceptors are dependent on nerve growth factor (NGF) during embryonic development, but a large subpopulation lose this dependence during embryonic and postnatal times and become responsive to the transforming growth factor beta family member, glial cell line-derived growth factor (GDNF).
Positive_regulation (dependent) of factor in Neurons associated with addiction, nerve growth factor and nociceptor
6) Confidence 0.10 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16540576 Disease Relevance 0.12 Pain Relevance 0.60
Nerve growth factor (NGF), which is a potent chemoattractant, is synthesized abundantly by cardiomyocytes and is induced by endothelin-1 upregulation in the heart.
Positive_regulation (induced) of factor in heart associated with nerve growth factor
7) Confidence 0.08 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18673222 Disease Relevance 1.25 Pain Relevance 0.41
In addition, the mRNA and protein levels of regenerating gene III beta (RegIIIbeta), a key factor in the pancreatic response to acute pancreatitis, were up-regulated at 24 h in wild-type mice upon cerulein administration, whereas they were attenuated in PACAP-Tg mice.
Positive_regulation (up-regulated) of factor associated with pancreatitis
8) Confidence 0.08 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19672038 Disease Relevance 0.89 Pain Relevance 0.26
Nerve growth factor (NGF), a potent chemoattractant, is synthesized abundantly by cardiomyocytes, and is induced by the upregulation of endothelin-1 during development.
Positive_regulation (induced) of factor in Nerve associated with nerve growth factor
9) Confidence 0.07 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19270423 Disease Relevance 1.00 Pain Relevance 0.40
The present study was performed to investigate the effect of beta-endorphin on macrophage colony-stimulating factor (M-CSF)-induced differentiation of macrophages from bone marrow cells in a semisolid culture system. beta-endorphin increased the number of macrophage colonies when bone marrow cells were cultured in the presence of M-CSF plus lipopolysaccharide (LPS).
Spec (investigate) Positive_regulation (-induced) of factor in macrophage
10) Confidence 0.07 Published 1995 Journal Blood Section Abstract Doc Link 7543304 Disease Relevance 0.12 Pain Relevance 0
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Positive_regulation (connective) of factor in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
11) Confidence 0.06 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.19 Pain Relevance 0.76
Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis, vascular permeability, and edema.
Positive_regulation (inducer) of factor associated with pressure and volume under development
12) Confidence 0.06 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12766200 Disease Relevance 0.26 Pain Relevance 0.16
Serum interleukin-6 rose rapidly, reaching a peak at hour 2 (P < .001) and then declining through hour 6, but interleukin-1 and tumor necrosis factor, were elevated in only a few animals undergoing laparotomy.
Positive_regulation (elevated) of factor
13) Confidence 0.06 Published 1996 Journal Reg Anesth Section Body Doc Link 8896011 Disease Relevance 0 Pain Relevance 0
The phosphorylation of ERK was reduced by tyrphostin AG1478, an inhibitor of phosphorylation of the epidermal growth factor receptor (EGFR), and by heparin, which neutralizes heparin-binding epithelial growth factor (HB-EGF), suggesting the involvement of a transactivation process, in which alpha(2)-adrenergic stimulation leads to proteolytic shedding of HB-EGF (and perhaps other EGFR agonists) from transmembrane-spanning precursors.
Positive_regulation (neutralizes) of factor associated with agonist
14) Confidence 0.06 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834899 Disease Relevance 0 Pain Relevance 0.12
We conclude that cAMP-elevating drugs shift the balance of T cell-derived cytokines from a proinflammatory to an enhanced anti-inflammatory factor release, thus protecting mice from TNF-mediated hepatic failure.
Positive_regulation (enhanced) of factor in T cell associated with liver failure, inflammation and cytokine
15) Confidence 0.05 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996181 Disease Relevance 0.68 Pain Relevance 0.27
Using a guinea pig model of liver injury induced by bioactivation of the anesthetic drug, halothane, we found that toxicity was commensurate with an increase in serum macrophage migration inhibitory factor (MIF), a pro-inflammatory signal and counter-regulator of glucocorticoids, but only in susceptible animals.
Positive_regulation (increase) of factor in macrophage associated with toxicity, inflammation, injury and halothane
16) Confidence 0.05 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12051698 Disease Relevance 0.85 Pain Relevance 0.37
After the hindpaw injection of formalin in mice, we measured changes in expression of immediate early genes including c-fos, c-jun, jun B, nerve growth factor induced genes (NGFI-A and NGFI-B) and activity-related cytoskeletal protein (ARC) using real-time PCR.
Positive_regulation (induced) of factor in nerve associated with nerve growth factor and aids-related complex
17) Confidence 0.04 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15389827 Disease Relevance 0.27 Pain Relevance 0.25
Phosphorylation of activating transcription factor in murine splenocytes through delta opioid receptors.
Positive_regulation (activating) of factor associated with delta opioid receptors
18) Confidence 0.04 Published 2003 Journal Cell. Immunol. Section Title Doc Link 12747953 Disease Relevance 0 Pain Relevance 0.38
These studies determined whether a DOR agonist alone ([D-Ala(2)-D-Leu(5)]enkephalin; DADLE) affects phosphorylation of the activating transcription factor (ATF-2) and its interaction with the MAPK, c-Jun NH(2)-terminal kinase (JNK).
Spec (whether) Positive_regulation (activating) of factor associated with agonist and enkephalin
19) Confidence 0.04 Published 2003 Journal Cell. Immunol. Section Abstract Doc Link 12747953 Disease Relevance 0 Pain Relevance 0.32
Induction of tumor necrosis factor-alpha in vivo by a skin irritant, tributyltin, through activation of transcription factors: its pharmacological modulation by anti-inflammatory drugs.
Positive_regulation (Induction) of factor in skin associated with necrosis, inflammation, cancer and cinod
20) Confidence 0.04 Published 1997 Journal J. Invest. Dermatol. Section Title Doc Link 9182817 Disease Relevance 0.61 Pain Relevance 0.21

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