INT164287

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.88
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ltb4r, Cysltr2) signal transducer activity (Ltb4r, Cysltr2) signal transduction (Ltb4r)
molecular_function (Cysltr2) cellular_component (Cysltr2)
Ltb4r (Rattus norvegicus)
Cysltr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 10 98.96 Very High Very High Very High
Spinal cord 6 97.60 Very High Very High Very High
Thermal hyperalgesia 10 95.60 Very High Very High Very High
Peripheral nerve injury 3 86.36 High High
Neuropathic pain 4 85.00 Quite High
IPN 4 80.96 Quite High
rheumatoid arthritis 5 79.60 Quite High
c fibre 2 77.60 Quite High
unmyelinated 4 76.80 Quite High
dorsal root ganglion 30 73.60 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 7 100.00 Very High Very High Very High
INFLAMMATION 10 98.96 Very High Very High Very High
Hyperalgesia 12 95.60 Very High Very High Very High
Eczema 1 94.52 High High
Asthma 3 93.64 High High
Neuropathic Pain 5 85.00 Quite High
Inflammatory Pain 4 80.96 Quite High
Rheumatoid Arthritis 5 79.60 Quite High
Disease 1 78.08 Quite High
Nociception 6 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Semi-quantitative RT-PCR revealed that 5-LO, FLAP, LTC4s, BLT1, and CysLT1 mRNAs increased following SNI, but not CysLT2 mRNAs.
BLT1 Positive_regulation (increased) of CysLT2 associated with nervous system injury
1) Confidence 0.41 Published 2010 Journal Glia Section Abstract Doc Link 19908283 Disease Relevance 1.10 Pain Relevance 0.61
LTB4 activates BLT1 and BLT2, and CysLTs activate CysLT1 and CysLT2.
BLT1 Positive_regulation (activate) of CysLT2
2) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.77 Pain Relevance 0.42

General Comments

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