INT1643

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Context Info
Confidence 0.26
First Reported 1975
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.45
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CSH1) extracellular region (CSH1)
Anatomy Link Frequency
follicle 1
muscle 1
skin 1
CSH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 11 100.00 Very High Very High Very High
Clonidine 6 100.00 Very High Very High Very High
Enkephalin 3 99.92 Very High Very High Very High
Analgesic 1 99.92 Very High Very High Very High
Opioid 4 99.52 Very High Very High Very High
Morphine 5 98.12 Very High Very High Very High
opiate 5 89.60 High High
Dismenorea 2 65.16 Quite High
antagonist 5 60.28 Quite High
agonist 3 55.84 Quite High
Disease Link Frequency Relevance Heat
Hutchinson-gilford Progeria Syndrome 41 99.16 Very High Very High Very High
Freckles 5 95.16 Very High Very High Very High
Cancer 16 94.32 High High
Intrahepatic Cholestasis 1 91.20 High High
Cockayne Syndrome 10 87.72 High High
Syndrome 17 84.68 Quite High
Skin Cancer 1 84.32 Quite High
Frailty 36 80.12 Quite High
Disease 15 75.12 Quite High
Apoptosis 9 72.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, how alterations in any of five NER-associated proteins (XPB, XPD, XPG, CSA, and CSB) can cause progeria remains largely obscure.
Regulation (alterations) of CSA associated with hutchinson-gilford progeria syndrome
1) Confidence 0.26 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 1.64 Pain Relevance 0.05
The modulation of placental lactogen release by opioids: a role for extracellular calcium.
Regulation (modulation) of placental lactogen associated with analgesic and opioid
2) Confidence 0.24 Published 1993 Journal Mol. Cell. Endocrinol. Section Title Doc Link 7684340 Disease Relevance 0 Pain Relevance 0.83
In order to estimate the human placental lactogen (HPL) level and its value as an indicator of fetoplacental function during labor, we determined HPL levels (N equals 225) before, during, and after labor in normal (N equals 16) and preeclamptic (N equals 14) subjects or in patients with benign intrahepatic cholestasis of pregnancy (N equals 5).
Regulation (value) of placental lactogen associated with intrahepatic cholestasis
3) Confidence 0.22 Published 1975 Journal Obstet Gynecol Section Abstract Doc Link 1153151 Disease Relevance 0.21 Pain Relevance 0
The effects of 2-Br-alpha-ergocryptine (2.5 mg/osM), clonidine (50 microgram, intramuscularly) and naloxone (0.4 mg, intramuscularly) as well as the interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone (LH) follicle-stimulating hormone (FSH), prolactin (PL) and thyroid-stimulating hormone (TSH) serum levels in normal man have been studied. 2-Br-alpha-ergocryptine and clonidine clearly reduce and naloxone tends to reduce PL serum levels.
Regulation (effects) of PL in follicle associated with narcan and clonidine
4) Confidence 0.22 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 223091 Disease Relevance 0 Pain Relevance 0.89
Sulpiride treatment during early human pregnancy: effect on the levels of prolactin, six steroids, and placental lactogen.
Regulation (effect) of placental lactogen
5) Confidence 0.18 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 7380989 Disease Relevance 0.19 Pain Relevance 0.07
The results have shown that morphine (100 nM) significantly stimulated hCG secretion by 6-8 weeks old trophoblast and was without effect on hPL.
Neg (without) Regulation (effect) of hPL associated with morphine
6) Confidence 0.10 Published 1988 Journal Life Sci. Section Abstract Doc Link 3362038 Disease Relevance 0 Pain Relevance 0.69
Similarly, [V]pl was increasingly dependent on qTotalVEGF,Normal but largely insensitive to qTotalVEGF,Calf, following the much larger intravasation flow from the normal compartment relative to that from the calf (Fig. 4).
Regulation (dependent) of pl
7) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
As a result, although there is relatively little change in the average CSA of type I fibers, the percentage of the total muscle cross-sectional area occupied by type I fibers tends to increase with age, whereas not only are type II fibers lost but the CSA and the aggregate power-generating capacity of the remaining fibers also decrease dramatically.
Neg (little) Regulation (change) of CSA in muscle
8) Confidence 0.04 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.21 Pain Relevance 0
A lipophilized ester-derivative of salicylic acid, capryloyl salicylic acid (CSA), has been shown to be an effective exfoliating agent due to its reduced penetration in the skin.34
Regulation (derivative) of CSA in skin
9) Confidence 0.04 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946856 Disease Relevance 0.13 Pain Relevance 0
RESULTS: The mean values of CSA-I, CSA-M, and CSA-O were 10.3, 9.8, and 8.7 mm2, respectively.
Regulation (values) of CSA-I
10) Confidence 0.02 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18311762 Disease Relevance 0.07 Pain Relevance 0

General Comments

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