INT164305

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.60
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nox4) oxidoreductase activity (Nox4) aging (Nox4)
cell morphogenesis (Nox4) endoplasmic reticulum (Nox4) plasma membrane (Nox4)
Anatomy Link Frequency
podocytes 1
Nox4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 86 87.04 High High
Hippocampus 17 85.80 High High
cerebral cortex 2 83.76 Quite High
Pyramidal cell 3 80.68 Quite High
member 8 1 63.72 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Proteinuria 2 96.32 Very High Very High Very High
Nephrosis 2 93.16 High High
Stress 26 87.44 High High
Cv General 4 Under Development 55 87.04 High High
Focal Segmental Glomerulosclerosis 3 86.88 High High
Death 19 85.04 High High
Cv Unclassified Under Development 30 81.56 Quite High
Injury 6 80.48 Quite High
Targeted Disruption 2 74.72 Quite High
Renal Disease 1 67.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In in vitro study, PAN significantly increased NOX4 and TRPC6 expression levels in cultured podocytes.
Positive_regulation (increased) of NOX4 in podocytes
1) Confidence 0.42 Published 2009 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 19910702 Disease Relevance 0.79 Pain Relevance 0.06
Rac1 GTPase may also be involved in activation of NOX1 and NOX3 isoforms, but it does not appear to be involved in activation of the NOX4, NOX 5 or Duox isoforms [30].
Positive_regulation (activation) of NOX4
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.81 Pain Relevance 0.46

General Comments

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