INT16431

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Context Info
Confidence 0.70
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 62
Total Number 63
Disease Relevance 6.28
Pain Relevance 23.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Lnpep) plasma membrane (Lnpep) intracellular (Lnpep)
cytoplasm (Lnpep)
Anatomy Link Frequency
PVN 5
neurons 5
SON 4
SCN 3
syncytiotrophoblast 2
Lnpep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 64 99.84 Very High Very High Very High
Endogenous opioid 23 99.84 Very High Very High Very High
narcan 92 99.82 Very High Very High Very High
amygdala 6 99.80 Very High Very High Very High
cva 12 99.72 Very High Very High Very High
agonist 43 99.66 Very High Very High Very High
tetrodotoxin 53 99.64 Very High Very High Very High
Opioid 20 99.60 Very High Very High Very High
Enkephalin 29 99.28 Very High Very High Very High
antagonist 32 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyponatremia 12 99.72 Very High Very High Very High
Hemorrhage 6 99.68 Very High Very High Very High
Stress 11 99.52 Very High Very High Very High
Pressure Volume 2 Under Development 15 99.48 Very High Very High Very High
Pancreatitis 4 99.08 Very High Very High Very High
Rheumatoid Arthritis 4 98.60 Very High Very High Very High
Volume Depletion And Dehydration 1 98.08 Very High Very High Very High
Disorders Of Creatine Metabolism 3 97.80 Very High Very High Very High
INFLAMMATION 3 97.76 Very High Very High Very High
Hypertension 12 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: Placental Leucine Aminopeptiadse (P-LAP) also known as oxytocinase, is secreted by syncytiotrophoblast and increases gradually during pregnancy until delivery.
Localization (secreted) of oxytocinase in syncytiotrophoblast
1) Confidence 0.70 Published 2010 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 20150869 Disease Relevance 0.24 Pain Relevance 0.13
OBJECTIVE: Placental Leucine Aminopeptiadse (P-LAP) also known as oxytocinase, is secreted by syncytiotrophoblast and increases gradually during pregnancy until delivery.
Localization (secreted) of P-LAP in syncytiotrophoblast
2) Confidence 0.69 Published 2010 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 20150869 Disease Relevance 0.24 Pain Relevance 0.13
In the amygdala, soluble oxytocinase and membrane enkephalinase activities decreased in stressed animals.
Localization (decreased) of oxytocinase in amygdala associated with amygdala
3) Confidence 0.63 Published 2009 Journal Neuropsychobiology Section Abstract Doc Link 19468242 Disease Relevance 0.50 Pain Relevance 0.51
The urinary excretion of proteins, N-acetyl-3-glucosaminidase and leucine aminopeptidase, was measured in 50 patients with rheumatoid arthritis (RA), of whom 20 subjects were on nonsteroidal anti-inflammatory drugs (NSAIDs) and 30 on gold salts.
Localization (excretion) of leucine aminopeptidase associated with inflammation, cinod and rheumatoid arthritis
4) Confidence 0.60 Published 1988 Journal Clin. Rheumatol. Section Abstract Doc Link 3229079 Disease Relevance 0.52 Pain Relevance 0.55
Oxytocinase is basically secreted by syncytiotrophoblast cells and rises progressively during pregnancy until the labor.
Localization (secreted) of Oxytocinase in syncytiotrophoblast cells
5) Confidence 0.60 Published 2005 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 16136013 Disease Relevance 0.09 Pain Relevance 0.09
These results suggest that the SFO efferents through the medial septum to the PVN exert a predominantly inhibitory influence on the excitability of putative vasopressin (VP)-secreting neurons in the PVN.
Localization (secreting) of VP in PVN
6) Confidence 0.60 Published 1988 Journal Neurosci. Lett. Section Abstract Doc Link 3185990 Disease Relevance 0 Pain Relevance 0.17
Evidence indicates that both VP- and prodynorphin-derived peptides are secreted under such conditions.
Localization (secreted) of VP
7) Confidence 0.52 Published 1986 Journal Fed. Proc. Section Abstract Doc Link 2874054 Disease Relevance 0.10 Pain Relevance 0.06
In contrast with the placenta where a significant portion of P-LAP is released, the enzyme was localized in the membrane fraction in brain and PC12 cells and no soluble form of the enzyme was detected.
Localization (released) of P-LAP in brain
8) Confidence 0.37 Published 2001 Journal Eur. J. Biochem. Section Abstract Doc Link 11389728 Disease Relevance 0.07 Pain Relevance 0.15
The pathogenesis of this effect is not known, but enhanced release of vasopressin (VP) and its renal actions may be a possible mechanism.
Localization (release) of VP
9) Confidence 0.37 Published 1998 Journal Endocrine Section Abstract Doc Link 9666340 Disease Relevance 0.26 Pain Relevance 0.41
Using the isolated rat hypothalamoneurohypophysial system, the effects of noradrenaline (NA) and some adrenoceptor agonists on vasopressin (VP) release and supraoptic neuronal activity were assessed in vitro.
Localization (release) of VP in neuronal associated with agonist and noradrenaline
10) Confidence 0.33 Published 1986 Journal Brain Res. Section Abstract Doc Link 3004655 Disease Relevance 0 Pain Relevance 0.41
These results suggest that the SFO efferents through the MnPO to the PVN may transmit the neuromodulatory signals which evoke long-duration increases in the excitability of putative vasopressin (VP)-secreting neurons in the PVN.
Localization (secreting) of VP in PVN
11) Confidence 0.32 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179725 Disease Relevance 0 Pain Relevance 0.17
Thus VP secreting neurons are excited to release VP by alpha 1-adrenoceptor activation.
Localization (release) of VP in neurons
12) Confidence 0.29 Published 1986 Journal Brain Res. Section Abstract Doc Link 3004655 Disease Relevance 0 Pain Relevance 0.40
The peak rate of VP release was reached shortly after the onset of burst discharge. when intraburst firing rate was highest, and both effects were dose-dependent when tested to different concentrations of phenylephrine.
Localization (release) of VP
13) Confidence 0.29 Published 1986 Journal Brain Res. Section Abstract Doc Link 3004655 Disease Relevance 0 Pain Relevance 0.45
Excess secretion of VP in combination with large fluid intake is known to induce hyponatremia.
Localization (secretion) of VP associated with hyponatremia
14) Confidence 0.28 Published 1998 Journal Endocrine Section Abstract Doc Link 9666340 Disease Relevance 0.27 Pain Relevance 0.42
We conclude that administration of fluoxetine to laboratory rats in the dose and duration used in this study does not significantly affect hypothalamic expression, pituitary stores, or peripheral secretion of VP.
Localization (secretion) of VP in pituitary associated with fluoxetine
15) Confidence 0.28 Published 1998 Journal Endocrine Section Abstract Doc Link 9666340 Disease Relevance 0.06 Pain Relevance 0.39
We determine if chronic fluoxetine administration in association with liberal fluid intake will induce hyponatremia via enhanced release of VP.
Localization (release) of VP associated with hyponatremia and fluoxetine
16) Confidence 0.28 Published 1998 Journal Endocrine Section Abstract Doc Link 9666340 Disease Relevance 0.34 Pain Relevance 0.42
Thus VP secreting neurons are excited to release VP by alpha 1-adrenoceptor activation.
Localization (secreting) of VP in neurons
17) Confidence 0.25 Published 1986 Journal Brain Res. Section Abstract Doc Link 3004655 Disease Relevance 0 Pain Relevance 0.41
NA and the alpha 1-agonist phenylephrine stimulated VP release and elicited bursts in tuberal supraoptic neurons, whereas isoprenaline (a beta-agonist) and clonidine (an alpha 2-agonist) did not.
Localization (release) of VP in neurons associated with agonist, noradrenaline and clonidine
18) Confidence 0.25 Published 1986 Journal Brain Res. Section Abstract Doc Link 3004655 Disease Relevance 0 Pain Relevance 0.47
Thus VP secreting neurons are excited to release VP by alpha 1-adrenoceptor activation.
Localization (release) of VP in neurons
19) Confidence 0.25 Published 1986 Journal Brain Res. Section Abstract Doc Link 3004655 Disease Relevance 0 Pain Relevance 0.41
Supraoptic nucleus (SON) neurons receive a dense innervation from noradrenergic fibers, the activity of which stimulates vasopressin (VP) and oxytocin (OT) release, notably during homeostatic regulation of blood pressure and volume.
Localization (release) of VP in SON
20) Confidence 0.25 Published 2007 Journal Neuroscience Section Abstract Doc Link 17693027 Disease Relevance 0 Pain Relevance 0.11

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