INT164323

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.38
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcg2) ATPase activity (Abcg2) plasma membrane (Abcg2)
nucleus (Abcg2)
Anatomy Link Frequency
MCF-7 4
Abcg2 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 20 99.98 Very High Very High Very High
cINOD 4 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Breast Cancer 16 99.84 Very High Very High Very High
INFLAMMATION 4 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone downregulates BCRP mRNA and protein expression in breast cancer cell lines.
Negative_regulation (downregulates) of Transcription (expression) of BCRP associated with breast cancer and dexamethasone
1) Confidence 0.21 Published 2009 Journal Oncol. Res. Section Title Doc Link 19911699 Disease Relevance 0.37 Pain Relevance 0.30
Dexamethasone showed a dose-independent and a time-dependent effect on decreasing the mRNA level of BCRP gene in comparison with control in MCF-7 and MCF-7/MX breast cancer cell lines, whereas no changes were noted in the presence of indomethacin.
Negative_regulation (decreasing) of Transcription (level) of BCRP in MCF-7 associated with breast cancer and dexamethasone
2) Confidence 0.15 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19911699 Disease Relevance 0.34 Pain Relevance 0.29
For evaluation of BCRP mRNA expression, relative quantitative PCR and comparative C1 method was exploited.
Negative_regulation (evaluation) of Transcription (expression) of BCRP
3) Confidence 0.15 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19911699 Disease Relevance 0.34 Pain Relevance 0.25
Dexamethasone showed a dose-independent and a time-dependent effect on decreasing the mRNA level of BCRP gene in comparison with control in MCF-7 and MCF-7/MX breast cancer cell lines, whereas no changes were noted in the presence of indomethacin.
Negative_regulation (decreasing) of Transcription (level) of BCRP in MCF-7 associated with breast cancer and dexamethasone
4) Confidence 0.05 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19911699 Disease Relevance 0.34 Pain Relevance 0.29

General Comments

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