INT164324

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.03
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcg2) ATPase activity (Abcg2) plasma membrane (Abcg2)
nucleus (Abcg2)
Anatomy Link Frequency
MCF-7 2
Abcg2 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 11 99.98 Very High Very High Very High
cINOD 2 97.84 Very High Very High Very High
methotrexate 70 89.76 High High
Glutamate 2 68.08 Quite High
Bioavailability 4 60.80 Quite High
adenocard 8 58.80 Quite High
Inflammation 3 56.08 Quite High
Arthritis 27 50.00 Quite Low
Potency 2 10.40 Low Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 9 99.84 Very High Very High Very High
INFLAMMATION 5 97.64 Very High Very High Very High
Rheumatoid Arthritis 11 73.92 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 63.44 Quite High
Myeloid Leukemia 86 52.48 Quite High
Juvenile Chronic Polyarthritis 23 50.00 Quite Low
Leukemia 14 50.00 Quite Low
Cancer 11 42.16 Quite Low
Death 3 41.76 Quite Low
Toxicity 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies have revealed that the cellular response to folate deprivation is associated with increased expression of FPGS and decreased expression of ABCG2 [35], suggesting that the adaptive cellular response to low folate involves increased polyglutamation to promote the retention of folate.
Negative_regulation (decreased) of Gene_expression (expression) of ABCG2
1) Confidence 0.45 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.13 Pain Relevance 0.36
This is the reason why BCRP mediated resistance to imatinib is attenuated by imatinib induced reduction of BCRP expression (Nakanishi et al 2006).


Negative_regulation (reduction) of Gene_expression (expression) of BCRP
2) Confidence 0.39 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.20 Pain Relevance 0.03
The level of BCRP protein, expressed as a ratio of the corresponding control, was decreased in dexamethasone-treated MCF-7/MX cells.
Negative_regulation (decreased) of Gene_expression (expressed) of BCRP in MCF-7 associated with dexamethasone
3) Confidence 0.15 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19911699 Disease Relevance 0.32 Pain Relevance 0.29
Dexamethasone downregulates BCRP mRNA and protein expression in breast cancer cell lines.
Negative_regulation (downregulates) of Gene_expression (expression) of BCRP associated with breast cancer and dexamethasone
4) Confidence 0.15 Published 2009 Journal Oncol. Res. Section Title Doc Link 19911699 Disease Relevance 0.37 Pain Relevance 0.30

General Comments

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