INT16433

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Context Info
Confidence 0.11
First Reported 1985
Last Reported 2007
Negated 2
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.32
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Lnpep) plasma membrane (Lnpep) intracellular (Lnpep)
cytoplasm (Lnpep)
Anatomy Link Frequency
blood 2
pituitary 2
SON 2
SCN 2
astrocytes 2
Lnpep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 18 100.00 Very High Very High Very High
Endogenous opioid 2 99.84 Very High Very High Very High
fluoxetine 7 98.26 Very High Very High Very High
antagonist 4 89.96 High High
opiate 1 89.52 High High
Neurotransmitter 1 81.04 Quite High
agonist 5 76.40 Quite High
Dopamine 16 75.32 Quite High
narcan 6 75.00 Quite High
dopamine receptor 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Hypertension 4 98.20 Very High Very High Very High
Sprains And Strains 1 84.40 Quite High
Decapitation 1 62.64 Quite High
Hyponatremia 3 42.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that administration of fluoxetine to laboratory rats in the dose and duration used in this study does not significantly affect hypothalamic expression, pituitary stores, or peripheral secretion of VP.
Regulation (affect) of Localization (secretion) of VP in pituitary associated with fluoxetine
1) Confidence 0.11 Published 1998 Journal Endocrine Section Abstract Doc Link 9666340 Disease Relevance 0.06 Pain Relevance 0.40
Using perifused explants of the rat suprachiasmatic nucleus (SCN), the effects of tetrodotoxin (TTX) on vasopressin (VP) release and its circadian profile were studied at various times throughout the circadian cycle.
Regulation (effects) of in SCN Localization (release) of VP in suprachiasmatic nucleus associated with tetrodotoxin
2) Confidence 0.09 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1933388 Disease Relevance 0 Pain Relevance 0.44
We hypothesized that an aberrant regulation of vasopressin (VP) and oxytocin (OT) release by endogenous opioid peptides alters this neuroendocrine system in the SHR.
Regulation (regulation) of Localization (release) of VP associated with endogenous opioid
3) Confidence 0.09 Published 1985 Journal Brain Res. Section Abstract Doc Link 3978414 Disease Relevance 0.26 Pain Relevance 0.17
The effects of porcine relaxin (pRXN) on arterial blood pressure and on the release of vasopressin (VP) and oxytocin (OT) were investigated in urethane-anesthetized rats at different stages of pregnancy and lactation.
Spec (investigated) Regulation (effects) of Localization (release) of VP in blood
4) Confidence 0.08 Published 1994 Journal Biol. Reprod. Section Abstract Doc Link 8167234 Disease Relevance 0 Pain Relevance 0
These results point to further implication of SON astrocytes in the regulation of VP and OT secretion, and suggest that they are potentially important elements participating in all regulatory processes of hypothalamo-neurohypophysial function that involve activation of noradrenergic pathways.
Regulation (regulation) of Localization (secretion) of VP in astrocytes
5) Confidence 0.07 Published 2007 Journal Neuroscience Section Abstract Doc Link 17693027 Disease Relevance 0 Pain Relevance 0.19
SON perfusion with TTX did not alter basal intranuclear VP or OT release or the intranuclear peptide response to direct NaCl stimulation of the SON.
Neg (not) Regulation (alter) of Localization (release) of VP in SON associated with tetrodotoxin
6) Confidence 0.02 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 8751288 Disease Relevance 0 Pain Relevance 0.78
Neither drug affected the basal release of OT or the basal or electrically stimulated release of VP.
Neg (Neither) Regulation (affected) of Localization (release) of VP
7) Confidence 0.02 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1831247 Disease Relevance 0 Pain Relevance 0.46

General Comments

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