INT164367

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.43
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NLRP1) nucleus (NLRP1) intracellular (NLRP1)
enzyme binding (NLRP1) cytoplasm (NLRP1)
Anatomy Link Frequency
embryo 2
NAc 2
NLRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 36 100.00 Very High Very High Very High
Ventral tegmentum 20 100.00 Very High Very High Very High
Nucleus accumbens 18 100.00 Very High Very High Very High
tolerance 9 99.88 Very High Very High Very High
Opioid 73 99.68 Very High Very High Very High
withdrawal 21 96.56 Very High Very High Very High
Locus ceruleus 13 94.64 High High
noradrenaline 11 90.68 High High
antagonist 2 88.64 High High
narcan 2 87.56 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 3 99.02 Very High Very High Very High
Substance Withdrawal Syndrome 8 96.92 Very High Very High Very High
Diarrhoea 1 93.00 High High
Cramps 1 92.44 High High
Anxiety Disorder 1 91.84 High High
Toxicity 9 90.60 High High
Syndrome 4 75.00 Quite High
Cognitive Disorder 5 73.16 Quite High
Poisoning 4 73.08 Quite High
Pressure Volume 2 Under Development 1 71.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, dopamine release in the VTA is linked to polymorphisms of the DRD2 gene and even attention-deficit hyperactivity disorder (ADHD), whereby carriers of the DRD2 A1 allele show a reduced NAc release of dopamine (DA).
Negative_regulation (reduced) of Localization (release) of NAc in NAc associated with nucleus accumbens, ventral tegmentum, dopamine and attention deficit hyperactivity disorder
1) Confidence 0.34 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19914781 Disease Relevance 0.49 Pain Relevance 0.94
We also examined whether NAC is effective at accelerating urinary excretion of MeHg in rats of both sexes and at different ages, and whether it can diminish MeHg levels in the developing embryo.
Negative_regulation (diminish) of Localization (excretion) of NAC in embryo
2) Confidence 0.27 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0.24 Pain Relevance 0
For example, opioid tolerance that reduces the VTA’s release of DA into the NAc may prevent the patient from obtaining pleasure from normally rewarding activities such as eating.
Negative_regulation (reduces) of Localization (release) of NAc associated with nucleus accumbens, ventral tegmentum, dopamine, tolerance and opioid
3) Confidence 0.07 Published 2002 Journal Sci Pract Perspect Section Body Doc Link PMC2851054 Disease Relevance 0.70 Pain Relevance 1.55

General Comments

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