INT164372

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.10
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
plasma membrane (Ngfr) nucleus (Ngfr) cytoplasm (Ngfr)
Anatomy Link Frequency
brain 4
neurite 2
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 43 100.00 Very High Very High Very High
Nerve growth factor 48 99.36 Very High Very High Very High
intrathecal 1 94.64 High High
Spinal cord 24 92.88 High High
cINOD 14 92.60 High High
adenocard 1 86.44 High High
Hippocampus 22 74.96 Quite High
long-term potentiation 15 67.32 Quite High
Inflammation 29 5.00 Very Low Very Low Very Low
cytokine 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 403 100.00 Very High Very High Very High
Injury 72 100.00 Very High Very High Very High
Cognitive Disorder 51 98.28 Very High Very High Very High
Stomach Cancer 9 97.48 Very High Very High Very High
Disease 399 97.28 Very High Very High Very High
Cancer 12 95.00 High High
Frailty 8 93.16 High High
Metastasis 4 89.32 High High
Death 171 88.32 High High
Brain Injury 50 70.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anticancer effects of R-flurbiprofen were found to require induction of p75(NTR) via the p38 signaling pathway, suggesting a possible mechanism of action.
Positive_regulation (require) of Positive_regulation (induction) of p75
1) Confidence 0.62 Published 2010 Journal Mol. Pharm. Section Abstract Doc Link 19916560 Disease Relevance 1.27 Pain Relevance 0.21
Rho activation by outgrowth inhibitors such as MAG and Nogo is mediated through p75NTR, which enhances the dissociation of the Rho-guanine nucleotide dissociation inhibitor (Rho-GDI) from RhoA after stimulation by the neurite outgrowth inhibitors (Yamashita and Tohyama 2003).
Positive_regulation (mediated) of Positive_regulation (activation) of p75NTR in neurite
2) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.13 Pain Relevance 0.11
NGF's growth-promoting effects are mediated via binding and activation of high affinity trkA Neurotrophin receptor [for review, see [46]].
Positive_regulation (mediated) of Positive_regulation (activation) of trkA Neurotrophin receptor associated with nerve growth factor
3) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.51 Pain Relevance 0.71
ProNGF levels were also found to be enhanced after CNS injury, together with upregulation of the p75 neurotrophin receptor and increased p75-mediated apoptosis [91].
Positive_regulation (enhanced) of Positive_regulation (upregulation) of p75 associated with injury, central nervous system and apoptosis
4) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.45 Pain Relevance 0.19
The model presented in Figure 4 indicates that mitochondria play a significant role in the amplification of the apoptotic processes initiated by growth factor deprivation, DD receptors activation (p75 and Fas), increased levels of intracellular Ca2+ linked to excitotoxicity and ROS accumulation in response to the many brain insults.

6.4.

Positive_regulation (role) of Positive_regulation (activation) of p75 in brain associated with apoptosis
5) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.38 Pain Relevance 0
The model presented in Figure 4 indicates that mitochondria play a significant role in the amplification of the apoptotic processes initiated by growth factor deprivation, DD receptors activation (p75 and Fas), increased levels of intracellular Ca2+ linked to excitotoxicity and ROS accumulation in response to the many brain insults.

6.4.

Positive_regulation (increased) of Positive_regulation (activation) of p75 in brain associated with apoptosis
6) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.37 Pain Relevance 0

General Comments

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