INT164381

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
Anatomy Link Frequency
spinal cord 2
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 5 100.00 Very High Very High Very High
Dynorphin 5 100.00 Very High Very High Very High
Opioid 1 97.84 Very High Very High Very High
anesthesia 3 96.56 Very High Very High Very High
Ultiva 3 96.12 Very High Very High Very High
Pain 4 90.80 High High
Hyperalgesia 1 85.12 High High
Dorsal horn 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 4 100.00 Very High Very High Very High
Nociception 2 97.40 Very High Very High Very High
Adenocarcinoma 10 93.36 High High
Pain 4 90.80 High High
Weight Loss 1 86.44 High High
Fatigue 1 85.92 High High
Hyperalgesia 1 85.12 High High
Cancer 1 65.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and the expression of c-Fos, prodynorphin (mRNA), and dynorphin in the spinal cord could participate in the molecular mechanisms underlying postoperative opioid-induced sensitization.
Regulation (participate) of Positive_regulation (activation) of ERK1 in spinal cord associated with dynorphin, opioid and spinal cord
1) Confidence 0.60 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 19917879 Disease Relevance 0.33 Pain Relevance 0.95
Due to the beneficial effect of sorafenib in HCC and strong activation of EGFR, ERK1 and AKT1, our patient received sorafenib.
Regulation (effect) of Positive_regulation (activation) of ERK1 associated with hepatocellular cancer
2) Confidence 0.19 Published 2010 Journal Onkologie Section Abstract Doc Link 20502062 Disease Relevance 1.16 Pain Relevance 0.09

General Comments

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