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Context Info
Confidence 0.75
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.20
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MAPK3, Fos) nucleoplasm (MAPK3) mitochondrion (MAPK3)
Golgi apparatus (MAPK3) DNA binding (Fos) protein complex assembly (MAPK3)
Anatomy Link Frequency
spinal cord 2
MAPK3 (Homo sapiens)
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 5 97.84 Very High Very High Very High
Dorsal horn 1 94.12 High High
Dynorphin 5 89.68 High High
Pain 3 84.08 Quite High
anesthesia 3 75.00 Quite High
Ultiva 3 75.00 Quite High
Hyperalgesia 1 62.64 Quite High
Opioid 1 57.12 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 76.64 Quite High
Hyperalgesia 1 62.64 Quite High
Pain 3 59.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that activated ERK1/2 could induce c-Fos expression and trigger the transcription of prodynorphin in the spinal cord.
ERK1 Positive_regulation (induce) of Gene_expression (expression) of c-Fos in spinal cord associated with spinal cord
1) Confidence 0.75 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 19917879 Disease Relevance 0.20 Pain Relevance 1.08

General Comments

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