INT1644

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Context Info
Confidence 0.55
First Reported 1975
Last Reported 2010
Negated 19
Speculated 5
Reported most in Abstract
Documents 77
Total Number 83
Disease Relevance 15.62
Pain Relevance 21.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
follicle 25
plasma 11
lymphocyte 4
thyroid 3
adrenal glands 2
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 198 100.00 Very High Very High Very High
agonist 65 100.00 Very High Very High Very High
Clonidine 31 100.00 Very High Very High Very High
Opioid 28 100.00 Very High Very High Very High
opioid receptor 18 100.00 Very High Very High Very High
opiate 16 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
Pain threshold 2 100.00 Very High Very High Very High
alcohol 21 99.98 Very High Very High Very High
antagonist 76 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 31 100.00 Very High Very High Very High
Reprotox - General 3 227 99.76 Very High Very High Very High
Endometriosis (extended) 215 99.08 Very High Very High Very High
Fibromyalgia 77 99.00 Very High Very High Very High
Hypogonadotropic Hypogonadism 86 98.52 Very High Very High Very High
Stress 30 97.00 Very High Very High Very High
Hemorrhage 16 96.72 Very High Very High Very High
Reprotox - General 1 44 96.32 Very High Very High Very High
Sleep Disorders 74 95.68 Very High Very High Very High
Ureteral Obstruction 2 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In postmenopausal women not subjected to any treatment, dermorphin infusion did not significantly modify plasma LH and FSH levels.
Neg (not) Regulation (modify) of FSH in plasma
1) Confidence 0.55 Published 1985 Journal Peptides Section Abstract Doc Link 3936026 Disease Relevance 0 Pain Relevance 0.29
No significant changes in FSH concentrations were observed during deltorphin, naloxone or deltorphin plus naloxone administration.
Neg (No) Regulation (changes) of FSH associated with narcan
2) Confidence 0.52 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9647539 Disease Relevance 0 Pain Relevance 0.58
The lowest dose (6 micrograms/kg) caused no change in serum LH and FSH.
Neg (no) Regulation (change) of FSH
3) Confidence 0.49 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3008020 Disease Relevance 0 Pain Relevance 0.49
The clinical significance of higher and more stable FSH levels for ovulation induction and IVF treatment, however, remains to be determined.
Regulation (significance) of FSH
4) Confidence 0.45 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
Physical examination, clinical history, and follicle-stimulating hormone (FSH) levels were sufficient for diagnosis in most cases.
Regulation (sufficient) of FSH in follicle
5) Confidence 0.45 Published 1987 Journal Obstet Gynecol Section Abstract Doc Link 3110713 Disease Relevance 0.47 Pain Relevance 0.15
Physical examination, clinical history, and follicle-stimulating hormone (FSH) levels were sufficient for diagnosis in most cases.
Regulation (sufficient) of follicle-stimulating hormone in follicle
6) Confidence 0.45 Published 1987 Journal Obstet Gynecol Section Abstract Doc Link 3110713 Disease Relevance 0.48 Pain Relevance 0.15
Pregnanolone did not induce any changes in estradiol, LH, FSH or prolactin plasma levels in either cycle phase.
Neg (not) Regulation (changes) of FSH in plasma
7) Confidence 0.43 Published 1999 Journal Gynecol. Endocrinol. Section Abstract Doc Link 10599553 Disease Relevance 0.34 Pain Relevance 0.34
Serum FSH concentrations were unaltered by exercise.
Regulation (unaltered) of FSH
8) Confidence 0.43 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 2948941 Disease Relevance 0 Pain Relevance 0.18
Naloxone had no effect on serum LH or FSH before or during the pulsatile administration.
Neg (no) Regulation (effect) of FSH associated with narcan
9) Confidence 0.41 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3101337 Disease Relevance 0.13 Pain Relevance 0.17
The effect of a dose of intravenous naloxone on serum levels of luteinising hormone (LH), follicle-stimulating hormone (FSH) and plasma cortisol was therefore investigated in ten normal subjects.
Spec (investigated) Regulation (effect) of FSH in follicle associated with narcan
10) Confidence 0.41 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3008020 Disease Relevance 0 Pain Relevance 0.38
The effect of a dose of intravenous naloxone on serum levels of luteinising hormone (LH), follicle-stimulating hormone (FSH) and plasma cortisol was therefore investigated in ten normal subjects.
Spec (investigated) Regulation (effect) of follicle-stimulating hormone in follicle associated with narcan
11) Confidence 0.41 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3008020 Disease Relevance 0 Pain Relevance 0.37
The purpose of this study was to evaluate the effects of dermorphin, a new synthetic powerful opiate-like heptapeptide, on plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in fertile and postmenopausal women.
Regulation (effects) of FSH in plasma associated with opiate
12) Confidence 0.41 Published 1985 Journal Peptides Section Abstract Doc Link 3936026 Disease Relevance 0 Pain Relevance 0.21
In a controlled study, the effect of a new enkephalin analogue (FW 34-569, Sandoz) on respiratory function (ventilatory response to CO2), pain threshold (hot plate technique), and plasma cortisol, prolactin, growth hormone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was investigated in six normal subjects.
Spec (investigated) Regulation (effect) of follicle-stimulating hormone in follicle associated with pain threshold and enkephalin
13) Confidence 0.40 Published 1981 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 6798813 Disease Relevance 0.17 Pain Relevance 0.59
Baseline levels of serum luteinizing hormone (LH), serum follicle-stimulating hormone (FSH), plasma testosterone, and prolactin were determined, and then the response of gonadotropin levels to stimulation with gonadotropin-releasing hormone (GnRH) was examined at 30, 60, 90, 120, and 180 minutes.
Regulation (response) of FSH in plasma
14) Confidence 0.40 Published 1996 Journal Endocr Pract Section Body Doc Link 15251556 Disease Relevance 0.09 Pain Relevance 0
Effect of delta-opioid receptor agonist deltorphin on circulating concentrations of luteinizing hormone and follicle stimulating hormone in healthy fertile women.
Regulation (Effect) of follicle stimulating hormone in follicle associated with narcan, agonist and opioid receptor
15) Confidence 0.38 Published 1998 Journal Hum. Reprod. Section Title Doc Link 9647539 Disease Relevance 0 Pain Relevance 0.58
The effects of 2-Br-alpha-ergocryptine (2.5 mg/osM), clonidine (50 microgram, intramuscularly) and naloxone (0.4 mg, intramuscularly) as well as the interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone (LH) follicle-stimulating hormone (FSH), prolactin (PL) and thyroid-stimulating hormone (TSH) serum levels in normal man have been studied. 2-Br-alpha-ergocryptine and clonidine clearly reduce and naloxone tends to reduce PL serum levels.
Regulation (effects) of follicle-stimulating hormone in follicle associated with narcan and clonidine
16) Confidence 0.37 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 223091 Disease Relevance 0 Pain Relevance 0.88
The effects of 2-Br-alpha-ergocryptine (2.5 mg/osM), clonidine (50 microgram, intramuscularly) and naloxone (0.4 mg, intramuscularly) as well as the interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone (LH) follicle-stimulating hormone (FSH), prolactin (PL) and thyroid-stimulating hormone (TSH) serum levels in normal man have been studied. 2-Br-alpha-ergocryptine and clonidine clearly reduce and naloxone tends to reduce PL serum levels.
Regulation (effects) of FSH in follicle associated with narcan and clonidine
17) Confidence 0.37 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 223091 Disease Relevance 0 Pain Relevance 0.89
A study on the effects of interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone, follicle-stimulating hormone, prolactin and thyroid-stimulating hormone levels in normal man serum.
Regulation (effects) of follicle-stimulating hormone in thyroid associated with narcan and clonidine
18) Confidence 0.37 Published 1979 Journal Neurosci. Lett. Section Title Doc Link 223091 Disease Relevance 0 Pain Relevance 0.92
The purpose of this study was to evaluate the effects of dermorphin, a new synthetic powerful opiate-like heptapeptide, on plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in fertile and postmenopausal women.
Regulation (effects) of stimulating hormone in plasma associated with opiate
19) Confidence 0.35 Published 1985 Journal Peptides Section Abstract Doc Link 3936026 Disease Relevance 0 Pain Relevance 0.21
Follicle-stimulating hormone, by contrast, was significantly lower than controls at 2200 h on Day 1 and remained low until 2200 h on Day 3 after mating.
Regulation (controls) of Follicle-stimulating hormone in Follicle
20) Confidence 0.32 Published 1985 Journal Biol. Reprod. Section Abstract Doc Link 3935183 Disease Relevance 0.16 Pain Relevance 0.08

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