INT164400

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.66
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CNTF) cytosol (CNTF) signal transduction (CNTF)
extracellular space (CNTF) growth (CNTF) nucleus (CNTF)
Anatomy Link Frequency
adipose tissue 1
HGF 1
ciliary 1
CNTF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 100.00 Very High Very High Very High
Central nervous system 4 99.68 Very High Very High Very High
Neuropathic pain 4 97.36 Very High Very High Very High
cytokine 3 95.68 Very High Very High Very High
Pain 3 85.68 High High
cva 51 79.80 Quite High
painful pain 2 75.00 Quite High
Sciatic nerve 1 62.00 Quite High
Hippocampus 10 53.52 Quite High
carpal tunnel syndrome 1 44.48 Quite Low
Disease Link Frequency Relevance Heat
Appetite Loss 33 99.84 Very High Very High Very High
Obesity 102 98.86 Very High Very High Very High
Neuropathic Pain 4 97.36 Very High Very High Very High
Weight Gain 5 90.72 High High
Hyperphagia 2 89.76 High High
Pain 2 85.68 High High
Cv General 4 Under Development 41 79.80 Quite High
Nociception 2 75.00 Quite High
Normal Pressure Hydrocephalus 1 75.00 Quite High
Motor Neuron Diseases 1 73.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies in experimental animals showed that neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), and nerve growth factor (NGF) might be involved in the pathophysiology of neuropathic pain.
Positive_regulation (derived) of CNTF in ciliary associated with nerve growth factor and neuropathic pain
1) Confidence 0.49 Published 2009 Journal Clin J Pain Section Abstract Doc Link 19920725 Disease Relevance 0.65 Pain Relevance 0.67
As in primary human MSCs, B10 cells express high levels of NGF, BDNF, CNTF, GDNF, bFGF, IGF-I, HGF and VEGF (Figure 10).
Positive_regulation (levels) of CNTF in HGF
2) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.25 Pain Relevance 0.20
The results of recent studies have suggested that CNTF and axokine may play a role in the regulation of adipocyte metabolism and, perhaps, the control of adipose tissue mass, supporting the hypothesis that weight loss due to CNTF is not solely mediated by the CNS [91].
Neg (not) Positive_regulation (mediated) of CNTF in adipose tissue associated with appetite loss, obesity and central nervous system
3) Confidence 0.22 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010692 Disease Relevance 0.76 Pain Relevance 0.08

General Comments

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